CAS No. 499-44-5

Batch: Purity:99.82
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β-thujaplicin Chemical Structure
Chemical Structure
Check the β-thujaplicin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one
CAS Number 499-44-5
Molecular Formula

C10H12O2
Molecular Weight (MW) 164.20
SMILES CC(C)C1=CC(=O)C(=CC=C1)O
InChIKey FUWUEFKEXZQKKA-UHFFFAOYSA-N

Ordering Information

Biological Activity

β-Thujaplicin (Hinokitiol) is a natural tropolone derivative and small-molecule iron ionophore that targets transmembrane iron transport mechanisms and downregulates expression of DNMT1 and UHRF1. It acts by transporting iron across lipid bilayers, thereby restoring intracellular iron assimilation and cellular homeostasis. Downstream, β-thujaplicin suppresses Nrf2 signaling pathways, resulting in inhibited cell proliferation, anti-oxidative responses, and anti-tumor activity in biological systems. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 32 mg/mL (194.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.