Bemcentinib (R428) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: Bemcentinib (R428)
Catalog Number: S2841
CAS Number: 1037624-75-1
IUPAC Name: 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. Hazard(s) identification

Classification of the substance or mixture:
GHS07: Acute toxicity - oral 4 H302 Harmful if swallowed.

Label elements:
The substance is classified and labeled according to the Globally Harmonized System (GHS).

Pictogram: GHS07

Signal word: Warning

Hazard statements:
H302 Harmful if swallowed.

Precautionary statements:

P264 Wash thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 If swallowed: Call a poison center/doctor if you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification system:

NFPA ratings (scale 0 - 4): Health = 2, Fire = 0, Reactivity = 0.
HMIS-ratings (scale 0 - 4): Health = 2, Fire = 0, Reactivity = 0.

Other hazards:

Results of PBT and vPvB assessment: Not applicable.
Hazards not otherwise classified: There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard.

3. Composition/information on ingredients

Chemical characterization: Substances
CAS No. Description: 1037624-75-1 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-

4. First-aid measures

Description of first aid measures:

General information: Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident is recommended.
After inhalation: Supply fresh air; consult doctor in case of complaints.
After skin contact: Generally the product does not irritate the skin.
After eye contact: Rinse opened eye for several minutes under running water.
After swallowing: Immediately call a doctor.

Most important symptoms and effects, both acute and delayed:
No further relevant information available.

Indication of any immediate medical attention and special treatment needed:
No further relevant information available.

5. Fire-fighting measures

Extinguishing media:

Suitable extinguishing agents: Use fire fighting measures that suit the environment. A solid water stream may be inefficient.

Special hazards arising from the substance or mixture:
No further relevant information available.

Advice for firefighters:

Protective equipment: No special measures required.

6. Accidental release measures

Personal precautions, protective equipment and emergency procedures:
Not required.

Environmental precautions:
Do not allow to enter sewers/surface or ground water.

Methods and material for containment and cleaning up:
Pick up mechanically.

Reference to other sections:
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

Protective Action Criteria for Chemicals:

PAC-1: Substance is not listed.
PAC-2: Substance is not listed.
PAC-3: Substance is not listed.

7. Handling and storage

Precautions for safe handling:
No special precautions are necessary if used correctly. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Keep away from sources of ignition. Take precautionary measures against static discharge.

Information about protection against explosions and fires:
No special measures required.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed. Store in accordance with information listed on the product insert.

Specific end use(s):
No further relevant information available.

8. Exposure controls/personal protection

Control parameters:

Components with limit values that require monitoring at the workplace: Not required.
Additional information: The lists that were valid during the creation were used as basis.

Exposure controls:

Appropriate engineering controls: No further data; see section 7.
Personal protective equipment:
- General protective and hygienic measures: Wash hands before breaks and at the end of work.
- Breathing equipment: Not required.
- Protection of hands: The glove material has to be impermeable and resistant to the product. Selection of the glove material should consider penetration times, rates of diffusion, and degradation.
- Material of gloves: Selection of suitable gloves depends on the material and quality marks, varying from manufacturer to manufacturer.
- Penetration time of glove material: The exact break through time has to be determined by the manufacturer and observed.
- Eye protection: Not required.

9. Physical and chemical properties

Information on basic physical and chemical properties:

Physical state: powder
Color: Not determined.
Odor: Characteristic
Structural Formula: C30H34N8
Molecular Weight: 506.6 g/mol
Odor threshold: Not determined.
Melting point/Melting range: Undetermined.
Boiling point/Boiling range: Undetermined.
Flammability: Product is not flammable.
Explosion limits: Lower: Not determined; Upper: Not determined.
Flash point: Not applicable.
Decomposition temperature: Not determined.
pH-value: Not applicable.
Viscosity (Kinematic/Dynamic): Not applicable.
Solubility in / Miscibility with Water: Not determined.
Solubility (DMSO): >5 mg/ml
Partition coefficient (n-octanol/water): Not determined.
Vapor pressure: Not applicable.
Density: Not determined.
Relative density: Not determined.
Vapor density: Not applicable.
Particle characteristics: Not determined.
Appearance (Form): powder
Ignition temperature: Not determined.
Danger of explosion: Product does not present an explosion hazard.
Evaporation rate: Not applicable.

10. Stability and reactivity

Reactivity:
No further relevant information available.

Chemical stability:
Stable under recommended storage conditions.

Thermal decomposition / conditions to be avoided:
No decomposition if used according to specifications.

Possibility of hazardous reactions:
No dangerous reactions known.

Conditions to avoid:
No further relevant information available.

Incompatible materials:
Strong oxidizing agents.

Hazardous decomposition products:
Carbon oxides, nitrogen oxides.

11. Toxicological information

Information on toxicological effects:

Acute toxicity: Harmful if swallowed.
Primary irritant effect:
- On the skin: No irritant effect.
- On the eye: No irritating effect.
Sensitization: No sensitizing effects known.
Interactive effects: No interactive effects between components are known.

Carcinogenic categories:

IARC (International Agency for Research on Cancer): Substance is not listed.
NTP (National Toxicology Program): Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration): Substance is not listed.

12. Ecological information

Toxicity:

Aquatic toxicity: No further relevant information available.

Persistence and degradability:
No further relevant information available.

Bioaccumulative potential:
No further relevant information available.

Mobility in soil:
No further relevant information available.

Results of PBT and vPvB assessment:
Not applicable.

Other adverse effects:

General notes: Water hazard class 1 (Self-assessment): slightly hazardous for water. Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.

13. Disposal considerations

Waste treatment methods:

Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system.

Uncleaned packagings:

Recommendation: Disposal must be made according to official regulations.

14. Transport information

UN-Number:

DOT, IMDG, IATA: not regulated

UN proper shipping name:

DOT, IMDG, IATA: not regulated

Transport hazard class(es):

DOT, ADN, IMDG, IATA Class: not regulated

Packing group:

DOT, IMDG, IATA: not regulated

Environmental hazards:
Not applicable.

Special precautions for user:
Not applicable.

Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code:
Not applicable.

UN "Model Regulation":
not regulated

15. Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture:
No further relevant information available.

Sara:

Section 355 (extremely hazardous substances): Substance is not listed.
Section 313 (Specific toxic chemical listings): Substance is not listed.
TSCA (Toxic Substances Control Act): Substance is not listed.
Hazardous Air Pollutants: Substance is not listed.

California Proposition 65:

Chemicals known to cause cancer: Substance is not listed.
Chemicals known to cause reproductive toxicity for females: Substance is not listed.
Chemicals known to cause reproductive toxicity for males: Substance is not listed.
Chemicals known to cause developmental toxicity: Substance is not listed.