Bemcentinib (R428) is a highly selective and potent AXL inhibitor. It affects PI3K/AKT, NF-κB, and STAT signaling pathways by blocking AXL phosphorylation, thereby inhibiting tumor proliferation, migration, and inflammation, and promoting apoptosis.
Bemcentinib (R428) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Bemcentinib (R428) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.