PT2977 (Belzutifan) is a potent HIF-2α inhibitor. It affects hypoxia signaling by binding to the HIF-2α PAS-B domain to disrupt HIF-2α/HIF-1β heterodimerization, effectively inhibiting hypoxia transcriptional programs, endothelial dysfunction, and tumor proliferation.
PT2977 (Belzutifan) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for PT2977 (Belzutifan) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.