CAS No. 843663-66-1

Batch: Purity:99.99
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Bedaquiline Chemical Structure
Chemical Structure
Check the Bedaquiline product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 843663-66-1
Molecular Formula

C32H31BrN2O2
Molecular Weight (MW) 555.50
SMILES CN(C)CCC(C1=CC=CC2=CC=CC=C21)(C(C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O

Ordering Information

Biological Activity

Bedaquiline (TMC-207) is a diarylquinoline inhibitor that specifically targets subunit c of mycobacterial ATP synthase. By blocking the activity of mycobacterial ATP synthase, bedaquiline disrupts bacterial energy generation, leading to rapid cellular ATP depletion and bactericidal action against Mycobacterium tuberculosis. Bedaquiline exhibits remarkable selectivity for mycobacterial ATP synthase over homologous eukaryotic enzymes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (59.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.