CAS No. 845533-86-0

Batch: Purity:99.99
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Bedaquiline fumarate Chemical Structure
Chemical Structure
Check the Bedaquiline fumarate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 845533-86-0
Molecular Formula

C32H31BrN2O2.C4H4O4
Molecular Weight (MW) 671.58
SMILES CN(C)CCC(C1=CC=CC2=CC=CC=C21)(C(C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O.C(=CC(=O)O)C(=O)O

Ordering Information

Biological Activity

Bedaquiline fumarate (TMC-207) is an oral diarylquinoline antimycobacterial agent that acts as a potent inhibitor of mycobacterial proton-translocating ATP synthase. By specifically targeting subunit c of the ATP synthase complex, it blocks ATP synthesis and depletes cellular energy reserves. This disruption of energy metabolism compromises bacterial survival, resulting in potent bactericidal activity against drug-susceptible and multidrug-resistant strains of Mycobacterium tuberculosis. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (148.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.