CAS No. 384859-58-9
Batch:
Purity:99.21
Chemical Structure
Check the
BCH001
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[[3-ethoxycarbonyl-6-(trifluoromethoxy)quinolin-4-yl]amino]benzoic acid | |
|---|---|---|
| CAS Number | 384859-58-9 | |
| Molecular Formula |
C20H15F3N2O5 |
|
| Molecular Weight (MW) | 420.34 | |
| SMILES | CCOC(=O)C1=CN=C2C=CC(=CC2=C1NC3=CC=CC=C3C(O)=O)OC(F)(F)F | |
| InChIKey | FWJMVZAVAUGMDX-UHFFFAOYSA-N |
Biological Activity
BCH001 is a small-molecule inhibitor of noncanonical poly(A) polymerase PAPD5. Inhibition of PAPD5 counteracts TERC RNA degradation, leading to the restoration of functional telomerase assemblies and stabilization of telomere length. Consequently, treatment with BCH001 recovers telomerase activity and reverses telomere attrition in induced pluripotent stem cells derived from patients with dyskeratosis congenita. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.