CAS No. 2222094-18-8
Batch:
Purity:99.99
Chemical Structure
Check the
BC1618
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(dibenzylamino)-3-[4-(trifluoromethyl)phenoxy]propan-2-ol | |
|---|---|---|
| CAS Number | 2222094-18-8 | |
| Molecular Formula |
C24H24F3NO2 |
|
| Molecular Weight (MW) | 415.45 | |
| SMILES | OC(COC1=CC=C(C=C1)C(F)(F)F)CN(CC2=CC=CC=C2)CC3=CC=CC=C3 | |
| InChIKey | LGTYABNNHILKHF-UHFFFAOYSA-N |
BC1618 is an orally active Fbxo48 inhibitor that stimulates adenosine monophosphate-activated protein kinase (AMPK)-dependent signaling. By inhibiting Fbxo48, the compound prevents AMPK degradation and promotes downstream AMPK pathway activation. These functional effects stimulate mitochondrial fission, facilitate cellular autophagy, and improve hepatic insulin sensitivity, helping to maintain metabolic homeostasis in target tissues.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 83 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.