CAS No. 2521285-05-0

Batch: Purity:99.33
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Sevabertinib (BAY 2927088) Chemical Structure
Chemical Structure
Check the Sevabertinib (BAY 2927088) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(3-chloro-2-methoxyanilino)-2-[3-[[(2S)-1,4-dioxan-2-yl]methoxy]-4-pyridinyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
CAS Number 2521285-05-0
Molecular Formula

C24H25ClN4O5
Molecular Weight (MW) 484.94
InChIKey VYQVHWNNPKOJEA-AWEZNQCLSA-N

Biological Activity

Sevabertinib (BAY 2927088) is a non-covalent, reversible, and selective tyrosine kinase inhibitor targeting mutant EGFR and HER2. It effectively suppresses signaling driven by EGFR and HER2 exon 20 insertion mutations in non-small-cell lung carcinoma models. By inhibiting receptor autophosphorylation and downstream oncogenic cascades, including the AKT and MAPK pathways, it blocks cell proliferation and induces apoptosis in mutant-driven tumor cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 48 mg/mL (98.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cancer Discov. 2018;8(7):OF5-OF5.

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Note: Technical data last updated: Sep 1, 2026.