CAS No. 196309-76-9
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| IUPAC Name | (E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile | |
|---|---|---|
| CAS Number | 196309-76-9 | |
| Molecular Formula |
C13H15NO2S |
|
| Molecular Weight (MW) | 249.33 | |
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N | |
| InChIKey | VHKZGNPOHPFPER-ONNFQVAWSA-N |
Bay 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation (IC50 = 10 μM). By blocking IκBα phosphorylation, it prevents nuclear translocation and activation of the NF-kB transcription factor pathway. This inhibition leads to reduced expression of downstream inflammatory targets, including endothelial adhesion molecules, and suppresses cell proliferation while promoting apoptosis, making it a useful tool for studying NF-kB signaling mechanisms. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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