CAS No. 1223498-69-8
Batch:
Purity:99.23
Chemical Structure
Check the
BAY 1000394
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3R)-3-[2-[4-(cyclopropylsulfonimidoyl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]oxybutan-2-ol | |
|---|---|---|
| CAS Number | 1223498-69-8 | |
| Molecular Formula |
C18H21F3N4O3S |
|
| Molecular Weight (MW) | 430.44 | |
| InChIKey | UELYDGOOJPRWGF-SRQXXRKNSA-N |
BAY 1000394 (Roniciclib) is a potent pan-CDK inhibitor targeting CDK1 (IC50 = 7 nM), CDK2 (IC50 = 9 nM), CDK4 (IC50 =, CDK7 (IC50 = 25 nM), and CDK9 (IC50 = 5 nM). By inhibiting cyclin-dependent kinase activity, it disrupts cell-cycle progression and transcriptional regulation, thereby triggering cell-cycle arrest and apoptosis in tumor cells and exhibiting strong preclinical antitumor efficacy. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 86 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.