CAS No. 126150-97-8
| IUPAC Name | acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate | |
|---|---|---|
| CAS Number | 126150-97-8 | |
| Molecular Formula |
C34H40N2O18 |
|
| Molecular Weight (MW) | 764.68 | |
| SMILES | CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C | |
| InChIKey | YJIYWYAMZFVECX-UHFFFAOYSA-N |
BAPTA-AM is a membrane-permeable, selective intracellular calcium chelator. Upon passive diffusion across cell membranes, cytosolic esterases cleave the acetoxymethyl ester groups to generate active BAPTA, which rapidly sequesters intracellular free calcium ions. This transient reduction in cytosolic calcium concentration disrupts downstream calcium-dependent signaling pathways, inhibiting cellular functions such as calcium-induced cell death, muscle contraction, and vesicle exocytosis. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(26.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(130.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
33 mg/mL
(43.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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