CAS No. 1230487-00-9
Batch:
Purity:99.96
Chemical Structure
Check the
Siponimod (BAF312)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[[4-[(E)-N-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-C-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid | |
|---|---|---|
| CAS Number | 1230487-00-9 | |
| Molecular Formula |
C29H35F3N2O3 |
|
| Molecular Weight (MW) | 516.6 | |
| SMILES | CCC1=C(C=CC(=C1)C(=NOCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)C)CN4CC(C4)C(=O)O | |
| InChIKey | KIHYPELVXPAIDH-HNSNBQBZSA-N |
Siponimod (BAF312) is a selective sphingosine-1-phosphate receptor agonist targeting S1P1 and S1P5, displaying over 1000-fold selectivity over S1P2, S1P3, and S1P4 receptors. Binding to S1P1 induces receptor internalization and inhibits lymphocyte egress from secondary lymphoid tissue into circulation. This receptor modulation suppresses downstream neuroinflammatory pathways and reduces pathogenic autoimmune cell infiltration. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(193.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(193.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(193.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 44 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(127.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Siponimod (BAF312) Clinical Trials
- Siponimod (BAF312) Solubility in DMSO
- Siponimod (BAF312) Stock Solution
- Siponimod (BAF312) Storage
- Siponimod (BAF312) Stability
- Siponimod (BAF312) Molecular Weight
- Siponimod (BAF312) SMILES
- Siponimod (BAF312) Chemical Structure (2D and 3D)
- Siponimod (BAF312) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.