CAS No. 1405-87-4
| IUPAC Name | (4R)-4-[[(2S)-2-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S,3S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid | |
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| CAS Number | 1405-87-4 | |
| Molecular Formula |
C65H101N17O16S |
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| Molecular Weight (MW) | 1408.67 | |
| SMILES | CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCCCCC(C(=O)NC(C(=O)N1)CCCN)NC(=O)C(C(C)CC)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C2CSC(=N2)C(C(C)CC)N)CC(=O)N)CC(=O)O)CC3=CN=CN3)CC4=CC=CC=C4 | |
| InChIKey | CLKOFPXJLQSYAH-ABRJDSQDSA-N |
Bacitracin is a cyclic polypeptide antibiotic that targets bacterial cell wall assembly by interfering with C55-isoprenyl pyrophosphate dephosphorylation. By binding the lipid pyrophosphate substrate in a metal ion-dependent manner, bacitracin prevents the recycling of lipid carriers required for peptidoglycan monomer transport across the inner membrane. This disruption of peptidoglycan synthesis impairs cell wall integrity and exerts potent antimicrobial activity against Gram-positive and select Gram-negative bacteria. [1]
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