CAS No. 1011529-10-4
| IUPAC Name | 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | |
|---|---|---|
| CAS Number | 1011529-10-4 | |
| Molecular Formula |
C9H11FN6O4 |
|
| Molecular Weight (MW) | 286.22 | |
| InChIKey | KTOLOIKYVCHRJW-XZMZPDFPSA-N |
Azvudine (RO- is a nucleoside reverse transcriptase inhibitor that potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50 range 0.018 to 0.025 nM). By targeting viral reverse transcriptase, it blocks viral reverse transcription and suppresses viral replication, demonstrating antiviral activity against human immunodeficiency virus, hepatitis B virus, and hepatitis C virus. Furthermore, azvudine retains inhibitory activity against nucleoside reverse transcriptase inhibitor-resistant HIV-1 strains. [1]
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Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 57 mg/mL |
| Ethanol | 57 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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