CAS No. 932986-18-0
Batch:
Purity:99.59
Chemical Structure
Check the
Azoramide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide | |
|---|---|---|
| CAS Number | 932986-18-0 | |
| Molecular Formula |
C15H17ClN2OS |
|
| Molecular Weight (MW) | 308.83 | |
| SMILES | CCCC(=O)NCCC1=CSC(=N1)C2=CC=C(C=C2)Cl | |
| InChIKey | VYBFWKKCWTXCQX-UHFFFAOYSA-N |
Biological Activity
Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It enhances endoplasmic reticulum (ER) protein-folding capacity and upregulates ER chaperones to protect cells from ER stress. By modulating UPR pathways, including PERK and IRE1α signaling, Azoramide improves cellular metabolic homeostasis, reduces insulin resistance, and restores function in models of obesity and metabolic dysfunction. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(197.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 61 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.