CAS No. 117772-70-0

Batch: Purity:100.0
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Azithromycin Dihydrate Chemical Structure
Chemical Structure
Check the Azithromycin Dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one;dihydrate
CAS Number 117772-70-0
Molecular Formula

C38H72N2O12.2H2O
Molecular Weight (MW) 785.02
SMILES CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O
InChIKey SRMPHJKQVUDLQE-KUJJYQHYSA-N

Ordering Information

Biological Activity

Azithromycin Dihydrate is an acid-stable macrolide antibiotic structurally related to erythromycin that targets the bacterial 50S ribosomal subunit. By binding to the 50S subunit, it blocks peptide translocation during protein synthesis, inhibiting nascent peptide chain elongation. This action disrupts bacterial protein production, leading to broad-spectrum antimicrobial activity against diverse Gram-positive and Gram-negative bacterial pathogens. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (127.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.