AZD1390 is a potent ATM inhibitor. It affects NF-κB, cGAS-STING, and c-NHEJ signaling pathways by restricting ATM nuclear translocation and suppressing DNA-PKcs activation, effectively inhibiting neuroinflammation, DSB repair, and cancer cell proliferation while promoting apoptosis.
AZD1390 Mechanism of Action: ATM Inhibition in Glioblastoma Cells Research
AZD1390 MOA：Targeting ATM/DNA Damage Response for Glioblastoma and Primary Brain Tumors