CAS No. 722543-31-9
Batch:
Purity:99.684
Chemical Structure
Check the
AZD1152(Barasertib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyl dihydrogen phosphate | |
|---|---|---|
| CAS Number | 722543-31-9 | |
| Molecular Formula |
C26H31FN7O6P |
|
| Molecular Weight (MW) | 587.54 | |
| InChIKey | GBJVVSCPOBPEIT-UHFFFAOYSA-N |
AZD1152 (Barasertib) is a potent, selective inhibitor of Aurora B kinase. In plasma, AZD1152 is rapidly converted to its active metabolite, AZD1152-HQPA, which selectively targets the Aurora B catalytic domain. Inhibition of Aurora B disrupts chromosome alignment and segregation during mitosis, impairing cytokinesis. Consequently, AZD1152 suppresses cell proliferation, prevents cell division, causes polyploidy, and induces apoptosis across multiple cancer cell lines. [1][2]
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Concentration
Volume
Mass
|
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(170.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
118 mg/mL
(200.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 118 mg/mL |
| Ethanol | 3 mg/mL |
| DMSO |
118 mg/mL
(200.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 118 mg/mL |
| Ethanol | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.