CAS No. 878385-84-3
| IUPAC Name | N-[2-[(2,3-difluorophenyl)methylsulfanyl]-6-[(2R,3S)-3,4-dihydroxybutan-2-yl]oxypyrimidin-4-yl]azetidine-1-sulfonamide | |
|---|---|---|
| CAS Number | 878385-84-3 | |
| Molecular Formula |
C18H22F2N4O5S2 |
|
| Molecular Weight (MW) | 476.52 | |
| SMILES | CC(C(CO)O)OC1=NC(=NC(=C1)NS(=O)(=O)N2CCC2)SCC3=C(C(=CC=C3)F)F | |
| InChIKey | QZECRCLSIGFCIO-RISCZKNCSA-N |
AZD5069 is a potent small-molecule antagonist of the chemokine receptor CXCR2 that selectively blocks CXCL8-mediated signaling. By inhibiting CXCR2 receptor activation, AZD5069 disrupts downstream intracellular signaling cascades, thereby suppressing neutrophil migration, chemotaxis, and myeloid-derived suppressor cell trafficking. Consequently, targeted inhibition of CXCR2 attenuates persistent inflammatory responses and modulates immune cell dynamics within the tumor microenvironment. [1][2]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(10.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 24 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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