CAS No. 1233339-22-4
Batch:
Purity:99.92
Chemical Structure
Check the
AZ20
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine | |
|---|---|---|
| CAS Number | 1233339-22-4 | |
| Molecular Formula |
C21H24N4O3S |
|
| Molecular Weight (MW) | 412.51 | |
| SMILES | CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4 | |
| InChIKey | SCGCBAAYLFTIJU-CQSZACIVSA-N |
AZ20 is a potent and selective small-molecule inhibitor of ATR kinase (IC50 5 nM) that demonstrates 8-fold selectivity over mTOR. Inhibition of ATR kinase activity by AZ20 blocks DNA damage checkpoint signaling, decreases CHK1 phosphorylation, and impairs homologous recombination repair. Consequently, treatment with AZ20 increases DNA double-strand breaks, inducing robust cell cycle arrest and apoptosis in replication-stressed cancer cell lines. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(201.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
83 mg/mL
(201.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.