CAS No. 1202757-89-8
Batch:
Purity:99.99
Chemical Structure
Check the
Spebrutinib (AVL-292)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-[[5-fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 1202757-89-8 | |
| Molecular Formula |
C22H22FN5O3 |
|
| Molecular Weight (MW) | 423.44 | |
| SMILES | COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F | |
| InChIKey | KXBDTLQSDKGAEB-UHFFFAOYSA-N |
Spebrutinib (AVL-292) is a covalent, orally active, and highly selective Bruton's tyrosine kinase (BTK) inhibitor (IC50 <. It selectively targets Cys481 of BTK to block B-cell receptor (BCR) signaling and downstream activation of the NF-kB pathway. Consequently, this inhibition reduces pro-inflammatory cytokine production, impairs osteoclast differentiation, and suppresses disease severity in preclinical animal models of rheumatoid arthritis. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(200.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Spebrutinib (AVL-292) Clinical Trials
- Spebrutinib (AVL-292) Solubility in DMSO
- Spebrutinib (AVL-292) Stock Solution
- Spebrutinib (AVL-292) Storage
- Spebrutinib (AVL-292) Stability
- Spebrutinib (AVL-292) Molecular Weight
- Spebrutinib (AVL-292) SMILES
- Spebrutinib (AVL-292) Chemical Structure (2D and 3D)
- Spebrutinib (AVL-292) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.