CAS No. 95233-18-4
| IUPAC Name | 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione | |
|---|---|---|
| CAS Number | 95233-18-4 | |
| Molecular Formula |
C22H19ClO3 |
|
| Molecular Weight (MW) | 366.84 | |
| SMILES | C1CC(CCC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=CC=C4C(=O)C3=O)O | |
| InChIKey | BSJMWHQBCZFXBR-UHFFFAOYSA-N |
Atovaquone is a potent antimicrobial hydroxy-1,4-naphthoquinone derivative that targets the mitochondrial cytochrome bc1 complex (Complex III). By selectively binding to the ubiquinol oxidation site of cytochrome bc1, it inhibits electron transport through the respiratory chain and collapses the mitochondrial membrane potential. This blockade impairs pyrimidine biosynthesis and ATP generation, ultimately suppressing metabolic activity and inducing parasite mortality. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
11 mg/mL
(29.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
5 mg/mL
(13.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.