CAS No. 82248-59-7
Batch:
Purity:99.96
Chemical Structure
Check the
Atomoxetine HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride | |
|---|---|---|
| CAS Number | 82248-59-7 | |
| Molecular Formula |
C17H21NO.HCl |
|
| Molecular Weight (MW) | 291.82 | |
| SMILES | CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl | |
| InChIKey | LUCXVPAZUDVVBT-UNTBIKODSA-N |
Biological Activity
Atomoxetine HCl is a selective norepinephrine transporter (NET) inhibitor (Ki of 5 nM) with 15-fold and 290-fold lower affinity for human serotonin and dopamine transporters, respectively. Inhibition of NET blocks norepinephrine reuptake, resulting in elevated extracellular levels of norepinephrine and dopamine, particularly within the prefrontal cortex. This enhancement of central monoaminergic neurotransmission regulates attention, cognitive performance, and behavioral responses in preclinical models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(198.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 37 mg/mL |
| Water | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.