CAS No. 82248-59-7
| IUPAC Name | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride | |
|---|---|---|
| CAS Number | 82248-59-7 | |
| Molecular Formula |
C17H21NO.HCl |
|
| Molecular Weight (MW) | 291.82 | |
| SMILES | CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl | |
| InChIKey | LUCXVPAZUDVVBT-UNTBIKODSA-N |
Atomoxetine HCl is a selective norepinephrine transporter (NET) inhibitor (Ki of 5 nM) with 15-fold and 290-fold lower affinity for human serotonin and dopamine transporters, respectively. Inhibition of NET blocks norepinephrine reuptake, resulting in elevated extracellular levels of norepinephrine and dopamine, particularly within the prefrontal cortex. This enhancement of central monoaminergic neurotransmission regulates attention, cognitive performance, and behavioral responses in preclinical models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(198.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 37 mg/mL |
| Water | 2 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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