CAS No. 29122-68-7
Batch:
Purity:99.88
Chemical Structure
Check the
Atenolol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 29122-68-7 | |
|---|---|---|
| Molecular Formula |
C14H22N2O3 |
|
| Molecular Weight (MW) | 266.34 | |
| SMILES | CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O |
Atenolol is a selective β1 adrenoceptor antagonist that binds human β1 adrenoceptor (log Kd −6.66), human β2 adrenoceptor (log Kd −5.99), and human β3 adrenoceptor (log Kd −4.11). By blocking β1-adrenergic receptors, atenolol inhibits G-protein-coupled signal transduction, reducing cAMP accumulation and PKA pathway activation. This blockade suppresses intracellular calcium influx, ultimately attenuating myocardial contractility and decreasing heart rate in cardiovascular model systems. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 53 mg/mL |
| Water | 35 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.