CAS No. 866541-93-7

Batch: Purity:99.81
Check CoA
(R)-(-)-Gossypol (AT-101) acetic acid Chemical Structure
Chemical Structure
Check the (R)-(-)-Gossypol (AT-101) acetic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name acetic acid;7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde
CAS Number 866541-93-7
Molecular Formula

C30H30O8.C2H4O2
Molecular Weight (MW) 578.61
SMILES CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O.CC(=O)O
InChIKey NIOHNDKHQHVLKA-UHFFFAOYSA-N

Ordering Information

Biological Activity

(R)-(-)-Gossypol (AT-101) acetic acid is an orally active small-molecule inhibitor that targets anti-apoptotic Bcl-2 family proteins, including Bcl-2, Bcl-xL, and Mcl-1. By blocking these key pro-survival signaling factors, AT-101 disrupts mitochondrial membrane integrity, triggering programmed cell death via the intrinsic apoptotic pathway along with cytoprotective autophagy in multiple human cancer cell models.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (172.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.