CAS No. 1071992-99-8
Batch:
Purity:99.96
Chemical Structure
Check the
Xevinapant (AT406)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5S,8S,10aR)-N-benzhydryl-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide | |
|---|---|---|
| CAS Number | 1071992-99-8 | |
| Molecular Formula |
C32H43N5O4 |
|
| Molecular Weight (MW) | 561.71 | |
| SMILES | CC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4 | |
| InChIKey | LSXUTRRVVSPWDZ-MKKUMYSQSA-N |
Xevinapant (AT406) is an orally active inhibitor of apoptosis protein (IAP) antagonist targeting cIAP1 (Ki 1.9 nM), cIAP2 (Ki 5.1 nM), and XIAP (Ki 66.4 nM). By mimicking the Smac AVPI peptide, it antagonizes XIAP to restore caspase-9 activity and induces rapid ubiquitination and degradation of cIAP1. Consequently, xevinapant promotes caspase cascade activation, triggers apoptosis, and suppresses tumor growth in preclinical human cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
112 mg/mL
(199.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 112 mg/mL |
| Water | Insoluble |
| DMSO |
112 mg/mL
(199.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 112 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(178.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(178.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(178.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Xevinapant (AT406) Clinical Trials
- Xevinapant (AT406) Solubility in DMSO
- Xevinapant (AT406) Stock Solution
- Xevinapant (AT406) Storage
- Xevinapant (AT406) Stability
- Xevinapant (AT406) Molecular Weight
- Xevinapant (AT406) SMILES
- Xevinapant (AT406) Chemical Structure (2D and 3D)
- Xevinapant (AT406) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.