CAS No. 1097917-15-1
Batch:
Purity:99.99
Chemical Structure
Check the
ASP3026
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine | |
|---|---|---|
| CAS Number | 1097917-15-1 | |
| Molecular Formula |
C29H40N8O3S |
|
| Molecular Weight (MW) | 580.74 | |
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC | |
| InChIKey | MGGBYMDAPCCKCT-UHFFFAOYSA-N |
ASP3026 is a novel and selective inhibitor of anaplastic lymphoma kinase (ALK). By targeting ALK kinase activity, the compound interrupts ALK-mediated oncogenic signaling through downstream effector pathways, such as STAT3, AKT/mTOR, and MAPK/ERK cascades. This pathway suppression results in impaired cell proliferation, cell cycle arrest, and the induction of apoptosis in ALK-driven cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
14 mg/mL
(24.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.