CAS No. 1126084-37-4
Batch:
Purity:98.2
Chemical Structure
Check the
ASP-9521
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [4-(2-hydroxy-2-methylpropyl)piperidin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone | |
|---|---|---|
| CAS Number | 1126084-37-4 | |
| Molecular Formula |
C19H26N2O3 |
|
| Molecular Weight (MW) | 330.42 | |
| SMILES | CC(C)(CC1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)OC)O | |
| InChIKey | OXSCPDKUZWPWFR-UHFFFAOYSA-N |
ASP-9521 is a selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5), also known as aldo-keto reductase family 1 member C3 (AKR1C3). By targeted inhibition of AKR1C3, it blocks the intratumoral conversion of weak precursors into potent androgen receptor ligands, disrupting androgen receptor-mediated transcription pathways. This inhibition ultimately suppresses steroid-driven tumor cell proliferation in castration-resistant models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 66 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.