CAS No. 648449-76-7
Batch:
Purity:99.92
Chemical Structure
Check the
AS-604850
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5Z)-5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylidene]-1,3-thiazolidine-2,4-dione | |
|---|---|---|
| CAS Number | 648449-76-7 | |
| Molecular Formula |
C11H5F2NO4S |
|
| Molecular Weight (MW) | 285.22 | |
| SMILES | C1=CC2=C(C=C1C=C3C(=O)NC(=O)S3)OC(O2)(F)F | |
| InChIKey | SRLVNYDXMUGOFI-YWEYNIOJSA-N |
AS-604850 is an ATP-competitive PI3K inhibitor targeting PI3Kγ, PI3Kα, PI3Kβ (IC50 >, and PI3Kδ (IC50 >. By blocking PI3Kγ kinase activity, it suppresses MCP-1-mediated monocyte chemotaxis and inhibits leukocyte recruitment during inflammatory responses. These downstream functional effects impair chemokine-induced cell migration and attenuate leukocyte infiltration in models of inflammation. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.