CAS No. 23964-57-0
| IUPAC Name | methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate;hydrochloride | |
|---|---|---|
| CAS Number | 23964-57-0 | |
| Molecular Formula |
C13H20N2O3S.HCl |
|
| Molecular Weight (MW) | 320.84 | |
| SMILES | CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC.Cl | |
| InChIKey | GDWDBGSWGNEMGJ-UHFFFAOYSA-N |
Articaine hydrochloride is a thiophene-containing amide local anesthetic that functions primarily as a voltage-gated sodium channel inhibitor. By blocking nerve impulse conduction along neuronal axons, it interrupts nociceptive signal transmission and produces localized analgesia. Additionally, articaine features an ester group that undergoes rapid hydrolysis by plasma and tissue esterases, contributing to its favorable pharmacokinetic profile and reduced systemic toxicity. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 64 mg/mL |
| Ethanol | 64 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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