Tucatinib (Irbinitinib, ONT-380, Arry-380): Selectivity & Specificity

Tucatinib is a potent inhibitor of HER2 (6.9 nM), HERG channel (13500 nM), EGFR, HER3, MAPK, PI3K, AKT. Tucatinib exhibits the greatest inhibitory potency toward HER2 (IC50 = 6.9 nM).