🎯 check Tucatinib (Irbinitinib, ONT-380, Arry-380) product page
Tucatinib is a potent, selective, ATP-competitive HER2 inhibitor. It affects Akt, mTOR, ERK, and JNK signaling pathways by binding to the HER2 kinase ATP-binding site and blocking its phosphorylation, thereby inhibiting tumor cell proliferation and promoting apoptosis.