CAS No. 1313883-00-9

Batch: Purity:99.75
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Miransertib (ARQ 092) HCl Chemical Structure
Chemical Structure
Check the Miransertib (ARQ 092) HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine;hydrochloride
CAS Number 1313883-00-9
Molecular Formula

C27H25ClN6
Molecular Weight (MW) 468.98
SMILES C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N.Cl
InChIKey DRHSWSSVIKDJME-UHFFFAOYSA-N

Ordering Information

Biological Activity

Miransertib (ARQ 092) HCl is an orally bioavailable, selective, allosteric pan-AKT inhibitor targeting AKT1, AKT2, and AKT3. By binding to the inactive conformation of AKT, it prevents plasma membrane translocation and activation of the kinase. Inhibition of AKT disrupts downstream AKT/mTOR pathway signaling, decreasing phosphorylation of key targets including PRAS40 and S6. This suppression attenuates cell proliferation, induces apoptosis, and suppresses tumor growth in preclinical models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 75 mg/mL (159.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.