CAS No. 74863-84-6

Batch: Purity:99.94
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Argatroban (MCI-9038) Chemical Structure
Chemical Structure
Check the Argatroban (MCI-9038) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid
CAS Number 74863-84-6
Molecular Formula

C23H36N6O5S
Molecular Weight (MW) 508.63
SMILES CC1CCN(C(C1)C(=O)O)C(=O)C(CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C
InChIKey KXNPVXPOPUZYGB-IOVMHBDKSA-N

Ordering Information

Biological Activity

Argatroban (MCI-9038) is a potent, selective synthetic direct thrombin inhibitor. By binding reversibly to the catalytic active site of thrombin, it blocks the conversion of fibrinogen to fibrin and prevents thrombin-induced activation of platelets and coagulation factors. Consequently, Argatroban suppresses the coagulation cascade, thrombus formation, and clot propagation, making it an effective tool for investigating anticoagulation pathways in cellular and biochemical assays. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 9 mg/mL (17.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 9 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.