CAS No. 141396-28-3
Batch:
Purity:99.99
Chemical Structure
Check the
Argatroban Monohydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid;hydrate | |
|---|---|---|
| CAS Number | 141396-28-3 | |
| Molecular Formula |
C23H36N6O5S.H2O |
|
| Molecular Weight (MW) | 526.65 | |
| SMILES | CC1CCN(C(C1)C(=O)O)C(=O)C(CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C.O | |
| InChIKey | AIEZTKLTLCMZIA-CZSXTPSTSA-N |
Argatroban Monohydrate is a direct, selective thrombin inhibitor that exerts potent anticoagulant effects. By reversibly binding to the catalytic site of thrombin, it prevents the conversion of fibrinogen to fibrin and blocks thrombin-induced activation of coagulation factors and platelet aggregation. This targeted inhibition effectively disrupts the thrombosis cascade and attenuates vascular clot formation. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(189.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 40 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.