Aprotinin: Selectivity & Specificity

Aprotinin is a potent inhibitor of plasma clots (530 nmol L/C01), JEV NS2B(H)-NS3pro (4.13 ± 0.17 mM), PAR-1 (50 KIU/mL), Kallikreins (plasma) (100.0 nM), Kallikreins (tissue) (1.0 nM), Kallikreins (urine, human) (0.1 nM), Kallikreins (urine, porcine) (1.7 nM), Kallikreins (pancreatic, porcine) (1.0 nM), Kallikreins (submandibular, porcine) (1.6 nM), F2 (61 µM), PLG (90 pM–4 nM), PLG (porcine) (4.0 nM), PLG (human) (0.23 nM), PLAT (8–27 µM), Plasminogen activator (27.0 µM), CTSG (10 nM), Chymostatin (10 nM), Chymotrypsin (bovine) (9.0 nM), Trypsin (bovine) (0.06 pM), Anhydrotrypsin (bovine) (<0.3 pM), Trypsinogen (bovine) (1.8 µM), CMA1, ELANE (3.5 µM), ELANE (human leucocytes) (3.5 µM), ELANE (recombinant aprotinins) (0.4 µM), TPSAB1, Tryptase TL-2, DPP3 (11.7 µM), MMP2, MMP9, F2R (50 KIU/mL), MASP3, MASP2 (150 nM), NOS2 (~IC50 600 KIU/mL), ENaC, SARS-CoV-2 (4–20.6 KIU/mL), SARS-CoV-1 (118 KIU/mL), FURIN (SARS-CoV-2 wild-type), FURIN (Omicron variant with S-P681R substitution), FURIN (Omicron variant with S-N679K/S-P681H substitutions), HA (Influenza A virus) (110 nM), HA (Influenza B virus) (39 nM), Amyloid fibrils (h-insulin), Amyloid fibrils (h-insulin, native Aprotinin), Amyloid fibrils (h-insulin, r-Aprotinin), Amyloid fibrils (h-insulin, 30-51SS), Amyloid fibrils (h-insulin, Ga-NOTA-r-Aprotinin), Kallikrein (200 KIU/ml). Aprotinin exhibits the greatest inhibitory potency toward Trypsin (bovine) (IC50 = 0.00006 nM).