CAS No. 541550-19-0
| IUPAC Name | N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine | |
|---|---|---|
| CAS Number | 541550-19-0 | |
| Molecular Formula |
C23H26N6O2 |
|
| Molecular Weight (MW) | 418.49 | |
| SMILES | CC1=CC(=CC=C1)C=NNC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4 | |
| InChIKey | HSKAZIJJKRAJAV-KOEQRZSOSA-N |
Apilimod (STA-5326) is a potent, cell-permeable PIKfyve inhibitor (IC50 = that selectively suppresses interleukin-12 (IL-12) and interleukin-23 (IL-23) cytokine production. By specifically inhibiting PIKfyve activity, apilimod disrupts phosphoinositide lipid metabolism and endolysosomal membrane trafficking pathways, thereby suppressing downstream inflammatory responses and cytokine expression in human monocytes and peripheral blood mononuclear cells. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
84 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
84 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
84 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
84 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- Apilimod (STA-5326) Clinical Trials
- Apilimod (STA-5326) Solubility in DMSO
- Apilimod (STA-5326) Stock Solution
- Apilimod (STA-5326) Storage
- Apilimod (STA-5326) Stability
- Apilimod (STA-5326) Molecular Weight
- Apilimod (STA-5326) SMILES
- Apilimod (STA-5326) Chemical Structure (2D and 3D)
- Apilimod (STA-5326) SDS｜MSDS