CAS No. 300815-04-7
| IUPAC Name | 2-(2-methyl-5-nitroimidazol-1-yl)ethyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate | |
|---|---|---|
| CAS Number | 300815-04-7 | |
| Molecular Formula |
C13H14Cl3N7O4 |
|
| Molecular Weight (MW) | 438.65 | |
| SMILES | CC1=NC=C(N1CCOC(=O)NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)[N+](=O)[O-] | |
| InChIKey | ZEXHXVOGJFGTRX-UHFFFAOYSA-N |
Apcin is a small-molecule inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that specifically targets and binds to the coactivator Cdc20. By binding Cdc20, Apcin competitively blocks its interaction with destruction box (D-box)-containing substrates, thereby preventing substrate ubiquitylation and degradation. This disruption of APC/C activity impairs mitotic progression and delays cell cycle transition. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(200.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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