Clinical Trials

Apatinib has been evaluated across numerous clinical trials spanning Early Phase 1 through Phase 3. Sponsored by academic institutions such as Sun Yat-sen University and Fudan University, alongside pharmaceutical companies including Jiangsu Hengrui Medicine and Elevar Therapeutics, this research focuses primarily on solid tumors, including hepatocellular carcinoma, biliary tract cancer, relapsed ovarian cancer, advanced gastric cancer, and triple-negative breast cancer. These global trials encompass a range of recruitment statuses, from actively recruiting and completed to suspended or unknown.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07371910 ACTIVE_NOT_RECRUITING
Metastatic Breast Cancer; HRD-Positive/HER2-Negative Advanced Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2024-06-12 PHASE3
NCT06255392 RECRUITING
Fludzoparib" and Anti-angiogenic; HRD-positive/HER2-negative Advanced Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2024-06-12 PHASE3
NCT02493582 ACTIVE_NOT_RECRUITING
Adenocarcinoma of Lung
The First People's Hospital of Changzhou
2015-07 PHASE2
NCT02485015 ACTIVE_NOT_RECRUITING
Stomach Neoplasms
The First People's Hospital of Changzhou
2015-06 PHASE2
NCT07587034 NOT_YET_RECRUITING
Liver Cancer
Shanghai Zhongshan Hospital
2026-06 PHASE1; PHASE2
NCT07267806 RECRUITING
Hepato Cellular Carcinoma (HCC); Chemotherapy Effect
Linhui Peng
2025-10-31 PHASE3
NCT06881017 NOT_YET_RECRUITING
Gastric Cancer; HER2 + Gastric Cancer; CLDN18.2-positive Adenocarcinoma of the Gastroesophageal Junction; PD-L1 Positive
China Medical University, China
2025-05-01 PHASE2
NCT06771154 NOT_YET_RECRUITING
Recurrent/Metastatic Endometrial Cancer
Peking Union Medical College Hospital
2025-04-01 PHASE2
NCT06181032 RECRUITING
Biliary Tract Malignancies
First Affiliated Hospital of Fujian Medical University
2023-12-23 PHASE1
NCT07802184 NOT_YET_RECRUITING
Locally Advanced Pancreatic Cancer; Metastatic Pancreatic Cancer
West China Hospital
2026-09-10 PHASE1; PHASE2
NCT06889688 RECRUITING
Breast Cancer Stage IV; Triple -Negative Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2025-02-21 PHASE3
NCT07589244 RECRUITING
HCC
Guangzhou Virotech Pharmaceutical Co., Ltd.
2026-05-13 PHASE2; PHASE3
NCT07790419 NOT_YET_RECRUITING
Liver Cancer
Zhai Wenlong
2026-08-30 PHASE4
NCT07610629 NOT_YET_RECRUITING
Gastric Adenocarcinoma
Henan Cancer Hospital
2026-05-05 PHASE2
NCT07569679 RECRUITING
Biliary Tract Cancer
Air Force Military Medical University, China
2025-12-10 PHASE2
NCT07357532 NOT_YET_RECRUITING
Small Cell Lung Carcinoma
Peking University Cancer Hospital & Institute
2026-01-31 PHASE2
NCT04803539 RECRUITING
Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2021-04-01 PHASE2; PHASE3
NCT06773156 ENROLLING_BY_INVITATION
Limited-stage Small Cell Lung Cancer (LS-SCLC)
Second Affiliated Hospital of Nanchang University
2024-11-01 PHASE2
NCT06172205 RECRUITING
BCLC Stage C Hepatocellular Carcinoma; Chemotherapy Effect
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2023-07-01 PHASE3
NCT06666166 NOT_YET_RECRUITING
Advanced Gastric Carcinoma; Advanced Gastroesophageal Junction Adenocarcinoma; Advanced Colorectal Cancer
Yunpeng Liu
2024-12 PHASE2
NCT07749859 NOT_YET_RECRUITING
Advanced Unresectable Hepatocellular Carcinoma
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2026-08 PHASE2
NCT07464756 RECRUITING
Gastric Adenocarcinoma
The First Affiliated Hospital with Nanjing Medical University
2026-04-03 PHASE2
NCT06339619 RECRUITING
Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2024-03-11 PHASE2
NCT07353684 RECRUITING
Adebrelimab; Adenocarcinoma of GE Junction; Adenocarcinoma of Stomach
Beijing Friendship Hospital
2025-05-11 PHASE2
NCT07324473 NOT_YET_RECRUITING
Hepatocellular Carcinomas; Resistance to Immunotherapy; Immunomodulation; Drug Repurposing
First Affiliated Hospital of Chongqing Medical University
2026-01-01 PHASE2
NCT07653451 NOT_YET_RECRUITING
Esophageal Squamous Cell Carcinoma
Peking University Cancer Hospital & Institute
2026-07-01 PHASE2; PHASE3
NCT06925243 RECRUITING
Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ]); Neoadjuvant Therapy; Adjuvant Chemotherapy; pCR Rate; MPR; ORR,OS,PFS
Zuoyi Jiao
2025-04-15 PHASE3
NCT07236528 NOT_YET_RECRUITING
Mucosal Melanoma
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
2025-11-30 PHASE2
NCT07154082 RECRUITING
Hepatocellular Carcinoma (HCC)
Wei Zhang
2025-12-30 PHASE2
NCT05582499 RECRUITING
Breast Neoplasm; Breast Cancer; Breast Tumors; Triple-Negative Breast Cancer (TNBC); HER2-positive Breast Cancer; HER2-negative Breast Cancer; Hormone Receptor Positive Tumor; Hormone Receptor Negative Tumor; Early-stage Breast Cancer; Locally Advanced Breast Cancer
Fudan University
2022-11-01 PHASE2
NCT07371871 NOT_YET_RECRUITING
Advanced Gastric Cancer
Anhui Provincial Cancer Hospital
2026-01-08
NCT07314372 NOT_YET_RECRUITING
Unresectable Hepatocellular Carcinoma (HCC); Hepatocellular Carcinoma (HCC); Liver Cancer Adult
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
2026-02-01 PHASE2
NCT07334483 RECRUITING
HCC
GrandPharma (China) Co., Ltd.
2025-08-22 PHASE2
NCT07773363 NOT_YET_RECRUITING
Pancreatic Cancer
Tang-Du Hospital
2026-08-30 PHASE2
NCT06614621 NOT_YET_RECRUITING
Extensive-Stage Small Cell Lung Cancer
Fujian Cancer Hospital
2025-02-01 PHASE2
NCT06749691 RECRUITING
Small Cell Lung Cancer Extensive Stage
Second Affiliated Hospital, Zhejiang University, School of Medicine
2024-12-28 PHASE2
NCT05192798 RECRUITING
Triple-negative Breast Cancer
The First Affiliated Hospital of Bengbu Medical University
2022-01-14 PHASE2
NCT03020979 RECRUITING
Malignant Ascites; Apatinib
The First Affiliated Hospital of Bengbu Medical University
2017-01 PHASE2
NCT07289997 RECRUITING
AFP Gastric or Gastroesophageal Junction Adenocarcinoma; PD-1/CTLA-4; AFPGC; Immunotherapy
Hebei Medical University Fourth Hospital
2025-09-28 PHASE2
NCT07314203 NOT_YET_RECRUITING
Gastric Cancer; Surgery
Fujian Medical University
2026-12-25 PHASE3
NCT07105748 RECRUITING
Mixed Hepatocellular-cholangiocarcinoma
Fudan University
2025-08-15 PHASE2
NCT06786312 NOT_YET_RECRUITING
Small Cell Lung Cancer Extensive Stage
Fujian Cancer Hospital
2025-01-25 PHASE2
NCT07294664 RECRUITING
Advanced Gastric Cancer; SHR1701
The First Affiliated Hospital of Zhengzhou University
2025-06-15 PHASE2
NCT07682272 NOT_YET_RECRUITING
Resectable Hepatocellular Carcinoma With Intermediate or High Recurrence Risk
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
2026-07 PHASE2
NCT07135544 RECRUITING
Biliary Tract Cancer; Biliary Tract Cancer (CCA)
Yongjun Chen
2025-08-14 PHASE2
NCT07033819 RECRUITING
Ovarian Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2025-06-25 PHASE2
NCT06925516 RECRUITING
Intrahepatic Cholangiocarcinoma (Icc)
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2025-04-25 PHASE2
NCT07192848 NOT_YET_RECRUITING
Hepatocellular Carcinoma Non-resectable
Song Peng
2025-09 PHASE2
NCT06385873 NOT_YET_RECRUITING
Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
The First Affiliated Hospital with Nanjing Medical University
2024-05-01 PHASE2
NCT06973330 NOT_YET_RECRUITING
AFP Gastric or Gastroesophageal Junction Adenocarcinoma
Anhui Provincial Cancer Hospital
2025-07 PHASE2
NCT06537505 NOT_YET_RECRUITING
Solid Tumor
Beidahuang Industry Group General Hospital
2024-08-05 PHASE2
NCT07618546 NOT_YET_RECRUITING
HCC - Hepatocellular Carcinoma
Henan Cancer Hospital
2026-05-25
NCT06280508 RECRUITING
Resectable Intrahepatic Cholangiocarcinoma With High Risk of Recurrence
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2024-03-01 PHASE2
NCT06360042 RECRUITING
Unresectable Hepatocellular Carcinoma
Peking University Cancer Hospital & Institute
2024-01-01 PHASE2
NCT06893887 RECRUITING
Hepatocellular Carcinoma(HCC)
Nanjing Tianyinshan Hospital
2025-05-22
NCT07479732 RECRUITING
Osteosarcoma; Osteosarcoma Metastatic
Peking University People's Hospital
2026-03-05 PHASE1; PHASE2
NCT06296563 RECRUITING
Intrahepatic Cholangiocarcinoma
Lei ZHAO
2024-03-01 PHASE2
NCT06447623 RECRUITING
Advanced Breast Cancer; HR+/HER2- Breast Cancer
Fudan University
2024-02-01 PHASE3
NCT06745193 NOT_YET_RECRUITING
Advanced Esophageal Carcinoma
Peking University
2025-02-01 PHASE2
NCT07031154 NOT_YET_RECRUITING
Non-Small Cell Lung Cancer; Adebrelimab; Apatinib
The First Affiliated Hospital of Xiamen University
2025-06-30 PHASE2
NCT06759090 NOT_YET_RECRUITING
Metastatic Pancreatic Carcinoma
Zhejiang University
2025-01-15 PHASE2
NCT06831175 RECRUITING
Adrenal Cortical Carcinoma; Adrenal Cortical Cancer; Adrenal Cancer
West China Hospital
2025-03-15 PHASE2
NCT06099821 RECRUITING
Digestive System Cancers
Peking University Cancer Hospital & Institute
2023-10-25 PHASE2
NCT05139095 RECRUITING
Gestational Trophoblastic Neoplasia
Peking Union Medical College Hospital
2022-01-27 PHASE2
NCT06749730 RECRUITING
Unresectable Biliary Tract Carcinoma
Henan Cancer Hospital
2024-04-01 PHASE2
NCT06538935 NOT_YET_RECRUITING
Hepatocellular Carcinoma; SBRT; Immune Checkpoint Blockade; Tyrosine Kinase Inhibitor
Fujian Cancer Hospital
2025-01 PHASE2
NCT06576973 RECRUITING
Esophageal Squamous Cell Carcinoma; Neoadjuvant Treatment
Second Affiliated Hospital, Zhejiang University, School of Medicine
2024-08-08 PHASE2
NCT07770113 RECRUITING
GC/GEJC
The First Affiliated Hospital of Zhengzhou University
2025-06-30 PHASE2
NCT06351020 ACTIVE_NOT_RECRUITING
Locally Advanced or Metastatic GC and GCJ Adenocarcinoma
LaNova Medicines Zhejiang Co., Ltd.
2024-06-24 PHASE3
NCT04072042 RECRUITING
Sarcoma
Ruijin Hospital
2019-10-30 PHASE2
NCT06913777 RECRUITING
Neoadjuvant Therapy
Fudan University
2025-04-08 PHASE3
NCT06546280 UNKNOWN
Hepatocellular Carcinoma
Zhujiang Hospital
2024-08-26 PHASE2
NCT06607770 RECRUITING
Lung Cancer
Zhou Chengzhi
2024-09-01 PHASE1; PHASE2
NCT04639180 ACTIVE_NOT_RECRUITING
Hepatocellular Carcinoma (HCC)
Jiangsu HengRui Medicine Co., Ltd.
2021-04-01 PHASE3
NCT05320692 ACTIVE_NOT_RECRUITING
Hepatocellular Carcinoma
Jiangsu HengRui Medicine Co., Ltd.
2022-08-09 PHASE3
NCT05934331 RECRUITING
Malignant Neoplasms of Digestive Organs
LaNova Medicines Zhejiang Co., Ltd.
2023-07-27 PHASE2
NCT06485466 RECRUITING
Unresectable Hepatocellular Carcinoma; Transarterial Chemoembolization; Camrelizumab; Apatinib
Guohui Xu
2024-08-10 PHASE3
NCT06281886 COMPLETED
Esophageal Squamous Cell Carcinoma; Efficacy; Toxicity
Sun Yat-sen University
2024-02-15 PHASE2
NCT06483282 RECRUITING
Small Cell Lung Cancer Limited Stage
Jin Ying
2024-06-21 PHASE2
NCT07157969 RECRUITING
HCC - Hepatocellular Carcinoma
Peking Union Medical College Hospital
2025-02-19 PHASE2
NCT06694324 NOT_YET_RECRUITING
Dedifferentiated Liposarcoma; Soft Tissue Sarcoma (STS)
Fudan University
2024-12-01 PHASE2
NCT06339281 NOT_YET_RECRUITING
Advanced Breast Cancer
Li Huiping
2024-05-01 PHASE2
NCT06346392 ACTIVE_NOT_RECRUITING
Gastric Cancer; Gastroesophageal Junction Cancer
AstraZeneca
2024-03-04 PHASE3
NCT06438627 RECRUITING
Nasopharyngeal Carcinoma
XIANG YANQUN
2024-05-30 PHASE3
NCT06693128 ACTIVE_NOT_RECRUITING
Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma
Ruijin Hospital
2024-11-21 PHASE2
NCT06349317 RECRUITING
Hepatocellular Carcinoma
Yongyi Zeng
2024-04-22 PHASE2
NCT06429696 RECRUITING
Small Cell Lung Cancer Extensive Stage
Nanfang Hospital, Southern Medical University
2024-07-14 PHASE2
NCT06363825 RECRUITING
Advanced Hepatocellular Carcinoma
Fujian Medical University
2024-04-12 PHASE2
NCT04834674 COMPLETED
Intrahepatic Cholangiocarcinoma; Transarterial Chemoembolization; Apatinib; PD-1 Antibody
Sichuan Cancer Hospital and Research Institute
2024-07-01 PHASE2
NCT04824352 SUSPENDED
Effect of Drug; Toxicity, Drug
Peking University People's Hospital
2021-04-01 PHASE2
NCT04342910 RECRUITING
Gastric Cancer
Jiangsu HengRui Medicine Co., Ltd.
2020-09-21 PHASE3
NCT06792162 RECRUITING
Gastric Cancer
Peking University Third Hospital
2023-04-20 PHASE2
NCT06280105 RECRUITING
Hepatocellular Carcinoma
Meng Chao Hepatobiliary Hospital of Fujian Medical University
2024-03-31 PHASE2
NCT07000344 TERMINATED
Ovarian Cancer
Peking Union Medical College Hospital
2025-07-01
NCT05027386 COMPLETED
Neuroblastoma
Sun Yat-sen University
2021-08-26 PHASE1; PHASE2
NCT06607107 RECRUITING
Hepatocellular Carcinoma Non-resectable
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2024-02-17 PHASE2
NCT05751733 RECRUITING
Gastrointestinal Stromal Tumors
Xiangya Hospital of Central South University
2023-02-01
NCT06482008 UNKNOWN
Hepatocellular Carcinoma
Sun Yat-sen University
2024-06-19 PHASE2
NCT04560127 ACTIVE_NOT_RECRUITING
Radioactive Iodine-refractory Differentiated Thyroid Cancer
Peking Union Medical College Hospital
2020-09-23 PHASE2
NCT05512481 RECRUITING
Melanoma; Acral Melanoma; Temozolomide; Apatinib; Camrelizumab; Neoadjuvant; Pathological Response
Peking University Cancer Hospital & Institute
2022-09-13 PHASE2
NCT05854849 RECRUITING
Nasopharyngeal Carcinoma
Sun Yat-sen University
2023-05-01 PHASE3
NCT06188455 NOT_YET_RECRUITING
Ovarian Cancer
The First Affiliated Hospital of Xiamen University
2024-12-01 PHASE3
NCT05594095 RECRUITING
Breast Neoplasm; Breast Cancer; Hormone Receptor Positive Tumor; HER2-negative Breast Cancer; Advanced Breast Cancer
Fudan University
2022-12-30 PHASE2
NCT05742750 COMPLETED
Locally Advanced Biliary Tract Cancer; Metastatic Biliary Tract Cancer
Sun Yat-sen University
2023-04-27 PHASE1; PHASE2
NCT06632522 NOT_YET_RECRUITING
Liver Cancer
Beijing Tsinghua Chang Gung Hospital
2024-10-20 PHASE2
NCT06418594 RECRUITING
HER2-negative Breast Cancer Brain Metastases
Beijing 302 Hospital
2024-10-10 PHASE2
NCT05759572 RECRUITING
Breast Cancer Metastatic
Fudan University
2023-02-01 PHASE2
NCT06102707 NOT_YET_RECRUITING
Ovarian Cancer Recurrent
Qilu Hospital of Shandong University
2023-11-01
NCT06539091 NOT_YET_RECRUITING
Epithelial Ovarian Cancer; Efficacy; Safety; Bone Mineral Density; Tolerability
Anhui Provincial Hospital
2024-10-01 PHASE3
NCT06592287 NOT_YET_RECRUITING
Advanced Gastric Cancer
Xianglin Yuan
2024-09-30 PHASE1; PHASE2
NCT05738434 RECRUITING
Esophageal Cancer by AJCC V8 Stage
The First Affiliated Hospital of Zhengzhou University
2023-03-02 PHASE2
NCT07026149 RECRUITING
Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma
Ruijin Hospital
2025-06-08 PHASE2
NCT05556200 UNKNOWN
Breast Cancer; Triple-Negative Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2022-12-01 PHASE2
NCT04501718 RECRUITING
Recurrent Medulloblastoma
Beijing Sanbo Brain Hospital
2020-10-28 PHASE2
NCT04501705 RECRUITING
Recurrent Atypical/malignant Meningioma
Beijing Sanbo Brain Hospital
2020-08-18
NCT06464614 UNKNOWN
Esophageal Cancer
The First Affiliated Hospital of Henan University of Science and Technology
2024-07-15 PHASE2
NCT06480864 RECRUITING
Small Cell Lung Cancer
Yunpeng Liu
2024-08-09
NCT05412589 UNKNOWN
Stage III Hepatocellular Cancer (CNLC Staging)
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2022-06-10 PHASE2
NCT05597527 UNKNOWN
Ovarian Cancer
Fujian Cancer Hospital
2022-11-01 PHASE2
NCT03164694 WITHDRAWN
Lung Cancer
Sun Yat-sen University
2017-05-20 PHASE2
NCT05839197 UNKNOWN
Macrotrabecular Massive Hepatocellular Carcinoma
Wan-Guang Zhang
2023-05-05 PHASE2
NCT05189184 UNKNOWN
Head and Neck Squamous Cell Carcinoma
The First Affiliated Hospital of Zhengzhou University
2022-03-30 PHASE2
NCT05853172 UNKNOWN
Gastric Cancer
Tianjin Medical University Cancer Institute and Hospital
2023-03-21 PHASE2
NCT06161272 UNKNOWN
Ovarian Cancer; High Grade Serous Adenocarcinoma of Ovary; Primary Peritoneal Carcinoma; Fallopian Tube Cancer
Guangxi Medical University
2023-12-10 PHASE2
NCT05699655 RECRUITING
Immunotherapy Gastrict Cancer
Fujian Cancer Hospital
2023-05-10 PHASE2; PHASE3
NCT03599778 UNKNOWN
Gastric Carcinoma
Anhui Provincial Hospital
2018-09-01 PHASE1; PHASE2
NCT06140732 UNKNOWN
Chordoma; Chemotherapy Effect
Xuanwu Hospital, Beijing
2023-10-30 PHASE2
NCT04749394 UNKNOWN
Locally Advanced Non-Small Cell Lung Cancer
Chinese Academy of Medical Sciences
2021-03-17 PHASE2
NCT06700421 ACTIVE_NOT_RECRUITING
Unresectable Locally Advanced Non-small Cell Lung Cancer
Wei Zhou
2024-08-13 PHASE2
NCT05451290 ACTIVE_NOT_RECRUITING
Advanced Biliary Tract Carcinoma
First Affiliated Hospital of Zhejiang University
2022-11-01 PHASE2
NCT06339216 NOT_YET_RECRUITING
Gastric Cancer
Chinese PLA General Hospital
2024-03-20 PHASE2
NCT04366128 COMPLETED
Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type
Rong Tao
2020-04-25
NCT06081595 NOT_YET_RECRUITING
Relapsed Ovarian Cancer
Jin Li
2023-10-30 PHASE2
NCT04714190 UNKNOWN
Gastric Cancer; HER2 Overexpressing Gastric Carcinoma
RemeGen Co., Ltd.
2021-03-24 PHASE3
NCT06482086 RECRUITING
Locally Advanced Thyroid Gland Carcinoma
West China Hospital
2021-06-01 PHASE2
NCT05019690 RECRUITING
Advanced Triple Negative Breast Cancer
Fujian Cancer Hospital
2021-10-01 PHASE1; PHASE2
NCT06125171 UNKNOWN
Osteosarcoma
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
2024-01 PHASE2
NCT05760430 UNKNOWN
Hepatocellular Carcinoma
Second Affiliated Hospital, Zhejiang University, School of Medicine
2022-12-14 PHASE2
NCT05313282 UNKNOWN
C-staged Hepatocellular Carcinoma in BCLC Classification
Sun Yat-sen University
2022-06-15 PHASE3
NCT04581473 ACTIVE_NOT_RECRUITING
Gastric Adenocarcinoma; Pancreatic Cancer; Gastroesophageal Junction Adenocarcinoma
CARsgen Therapeutics Co., Ltd.
2020-10-23 PHASE1; PHASE2
NCT05062837 UNKNOWN
Hepatocellular Carcinoma
Guangxi Medical University
2021-06-01 PHASE2; PHASE3
NCT05524974 NOT_YET_RECRUITING
Locally Advanced Gastric Cancer
Fujian Medical University
2022-09-01 PHASE2
NCT05235100 COMPLETED
Sarcoma,Soft Tissue; Extremity; Trunk; Intensity-modulated Radiotherapy; Targetd Therapy; Major Wound Complications
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2021-09-01 PHASE2
NCT04559607 UNKNOWN
Hepatocellular Carcinoma
Zhongda Hospital
2020-09-11
NCT05069857 RECRUITING
Oral Squamous Cell Carcinoma; Neoadjvant Therapy; Anti-PD-1; Anti-VEGFR
Shanghai Jiao Tong University School of Medicine
2021-09-01 PHASE2
NCT04074564 UNKNOWN
Sarcoma
HRYZ Biotech Co.
2019-11-22 EARLY_PHASE1
NCT04781686 UNKNOWN
Metastatic Gastric Adenocarcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma
Zhou Fuxiang
2021-05-14 PHASE2
NCT04454905 UNKNOWN
Intrahepatic Cholangiocarcinoma
Sun Yat-sen University
2020-08-01 PHASE2
NCT05932264 UNKNOWN
NSCLC; Non-small Cell Lung Cancer
Sun Yat-sen University
2023-07 PHASE2
NCT05156970 COMPLETED
Recurrent Head and Neck Squamous Cell Carcinoma; Metastatic Head and Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
2021-06-24 PHASE2
NCT05216237 UNKNOWN
Gastric Cancer; Chemotherapy; Immunotherapy
Jiuda Zhao
2022-02-15 PHASE2
NCT04930315 COMPLETED
Hepatocellular Carcinoma
Zhejiang University
2021-09-15 PHASE2
NCT05380986 UNKNOWN
Solid Tumor
Henan Cancer Hospital
2022-05-20
NCT05559008 UNKNOWN
Peripheral T Cell Lymphoma
Ruijin Hospital
2022-09-30 PHASE1; PHASE2
NCT04701060 COMPLETED
Resectable Hepatocellular Carcinoma
Tianjin Medical University Cancer Institute and Hospital
2021-01-26 PHASE2
NCT05099848 COMPLETED
Hepatocellular Carcinoma
Shandong Cancer Hospital and Institute
2021-03-17 PHASE2
NCT05142865 UNKNOWN
Advanced or Metastatic EP-NEC
Huazhong University of Science and Technology
2022-01-14 PHASE2
NCT04974944 TERMINATED
Stage IVB Cervical Cancer; Recurrent Cervical Cancer; Persistent Cervical Cancer
Sun Yat-Sen University Cancer Center
2021-07-30 PHASE2
NCT05447702 RECRUITING
Triple Negative Breast Cancer
West China Hospital
2022-11-01 PHASE2
NCT04609176 UNKNOWN
Gastric Cancer
Peking University
2020-11-18 PHASE2
NCT04191889 UNKNOWN
C-staged Hepatocellular Carcinoma in BCLC Classification
Sun Yat-sen University
2020-04-13 PHASE2
NCT05400902 UNKNOWN
Intrahepatic Cholangiocarcinoma
Binkui Li
2023-05-31 PHASE2
NCT04950400 UNKNOWN
Non-small Cell Lung Cancer
Beijing Chest Hospital
2021-07-07
NCT04318730 UNKNOWN
Adrenocortical Carcinoma
West China Hospital
2020-10-01 PHASE2
NCT02824458 UNKNOWN
EGFR Tyrosine Kinase Inhibitors Plus VEGFR Inhibitors
Sun Yat-sen University
2016-06 PHASE3
NCT04517357 COMPLETED
Relapsed Ovarian Cancer
Jiangsu HengRui Medicine Co., Ltd.
2020-10-16 PHASE2
NCT03742193 UNKNOWN
Osteosarcoma; Pulmonary Metastases; Apatinib
Ruijin Hospital
2019-08-11 PHASE2
NCT05550025 UNKNOWN
Hepatocellular Carcinoma
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2021-12-17 PHASE2
NCT05479487 UNKNOWN
Relapsed Ovarian Cancer
Xiaohua Wu MD
2022-08-01 PHASE2
NCT04683198 UNKNOWN
Small-cell Lung Cancer
Chinese Academy of Medical Sciences
2021-04-01 PHASE2
NCT03917966 UNKNOWN
Locally Advanced Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital of Zhengzhou University
2020-04-07 PHASE2
NCT04588987 UNKNOWN
Neoadjuvant Therapy; Carilizumab; Apatinib; Recurrent High-Grade Glioma
Sun Yat-sen University
2020-10 PHASE2
NCT05942573 UNKNOWN
Gastric Cancer (GC) Gastroesophageal Junction Cancer (GEJ)
Tianjin Medical University Cancer Institute and Hospital
2022-12-24 PHASE2
NCT04625803 COMPLETED
Colon Cancer; Neoadjuvant Therapy
Zhejiang University
2021-01-04 PHASE2
NCT05549466 UNKNOWN
Nasopharyngeal Carcinoma
Sun Yat-sen University
2022-10-08 PHASE2
NCT04190745 UNKNOWN
Gastric Adenocarcinoma
Zhejiang Cancer Hospital
2019-11-29 PHASE2
NCT04715633 UNKNOWN
Colorectal Cancer; Microsatellite Instability High
Sun Yat-sen University
2020-12-01 PHASE2
NCT04479527 UNKNOWN
Hepatocellular Carcinoma
Peking University Cancer Hospital & Institute
2021-04 PHASE2
NCT04863430 WITHDRAWN
Gastric Cancer
Peking University
2021-05-11 PHASE2
NCT05277480 COMPLETED
Effect of Drug; Drug; Toxicity
Peking University People's Hospital
2022-03-01 PHASE2
NCT04229615 UNKNOWN
Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Carcinoma
Jiangsu HengRui Medicine Co., Ltd.
2020-06-02 PHASE3
NCT03777124 TERMINATED
NSCLC Stage IV; KRAS Gene Mutation; PD-1 Antibody; Chemotherapy Effect
Jiangsu HengRui Medicine Co., Ltd.
2019-07-11 PHASE2
NCT04012827 UNKNOWN
Soft Tissue Sarcoma
Sun Yat-sen University
2019-08-20 PHASE2
NCT03813784 COMPLETED
Gastric Cancer; GastroEsophageal Cancer
Jiangsu HengRui Medicine Co., Ltd.
2019-03-07 PHASE3
NCT03491631 UNKNOWN
Tumor, Solid; Cancer, Metastatic; Neoplasm Malignant
Jiangsu HengRui Medicine Co., Ltd.
2018-11-20 PHASE1
NCT04934618 UNKNOWN
Gastric Cancer
Nanfang Hospital, Southern Medical University
2020-05-19 PHASE2
NCT04459078 UNKNOWN
Adenocarcinoma of the Lung
Hunan Cancer Hospital
2020-08-26 PHASE2
NCT05342389 UNKNOWN
Metastatic Gastric Adenocarcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma
Sixth Affiliated Hospital, Sun Yat-sen University
2022-05-01 PHASE2
NCT05290116 UNKNOWN
Intrahepatic Cholangiocarcinoma
Yunfei Yuan
2022-07-21 PHASE2
NCT05839197 Recruiting
Macrotrabecular Massive Hepatocellular Carcinoma
Wan-Guang Zhang|Tongji Hospital
2023-05-05 Phase 2
NCT04720131 COMPLETED
Biliary Tract Cancer; Anti-PD-1 Therapy; Targeted Molecular Therapy; Capecitabine
Beijing Friendship Hospital
2021-01-01 PHASE2
NCT05223088 COMPLETED
Immunotherapy; Gastrict Cancer
Fujian Cancer Hospital
2021-10-31 PHASE2
NCT04335006 TERMINATED
Breast Cancer; Triple Negative Breast Cancer
Jiangsu HengRui Medicine Co., Ltd.
2020-07-14 PHASE3
NCT04832204 UNKNOWN
Solid Tumor
Beijing Hospital
2021-03-25 PHASE2
NCT04723030 UNKNOWN
Locally Advanced Pancreatic Cancer
Peking University
2021-04-01 PHASE2
NCT05265793 UNKNOWN
PD-1 Immunotherapy; VEGFR-TKI; Sarcomatoid Carcinoma; Carcinosarcoma
Fudan University
2021-11-21 PHASE2
NCT03982485 ACTIVE_NOT_RECRUITING
Breast Cancer
RenJi Hospital
2018-10-16 PHASE2
NCT06238752 COMPLETED
Advanced Gastric Adenocarcinoma
Renmin Hospital of Wuhan University
2021-03-01 PHASE2
NCT05742750 Not yet recruiting
Locally Advanced Biliary Tract Cancer|Metastatic Biliary Tract Cancer
Sun Yat-sen University|Jiangsu Hengrui Pharmaceutical Co. Ltd.
2023-03-01 Phase 1|Phase 2
NCT05095636 UNKNOWN
Gastric Cancer; Metastasis
Fudan University
2021-03-17 PHASE2
NCT04258644 UNKNOWN
Gastric Cancer
Beijing Friendship Hospital
2020-03-01 PHASE2
NCT04569916 UNKNOWN
Solid Tumor
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
2020-09 PHASE2
NCT05001412 UNKNOWN
Extensive Stage Small Cell Lung Cancer
Zhou Chengzhi
2021-01-27 PHASE1
NCT04425135 UNKNOWN
Lung Neoplasms
The First Affiliated Hospital of Xiamen University
2020-07 PHASE2
NCT04850040 UNKNOWN
Hepatocellular Carcinoma Resectable
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2021-05-06 PHASE2
NCT04722718 UNKNOWN
Breast Cancer
Jiuda Zhao
2021-02-01 PHASE2
NCT05171309 UNKNOWN
Hepatocellular Carcinoma
Nanfang Hospital, Southern Medical University
2021-01-01 PHASE2
NCT03365765 COMPLETED
Apatinib
Huashan Hospital
2018-02-12 PHASE3
NCT05049681 UNKNOWN
Esophageal Cancer
Feng Wang
2021-12-05 PHASE3
NCT03193814 WITHDRAWN
Colorectal Cancer; Chemotherapy; Angiogenesis
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
2019-12-01 PHASE2
NCT04612894 UNKNOWN
Thyroid Cancer
Fudan University
2020-12-01 PHASE2
NCT04267549 UNKNOWN
Gastric Cancer Stage IV
Tianjin Medical University Cancer Institute and Hospital
2019-05-01 PHASE2
NCT04303741 UNKNOWN
Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2020-03-25 PHASE2
NCT03741244 UNKNOWN
Glioma
The Second Hospital of Hebei Medical University
2019-05-06 PHASE2
NCT04547088 UNKNOWN
Nasopharyngeal Carcinoma
Sun Yat-sen University
2020-09 PHASE2
NCT04878107 UNKNOWN
Non-Small Cell Lung Cancer
Wuhan University
2022-03-15 PHASE2
NCT04548271 UNKNOWN
Nasopharyngeal Carcinoma
Sun Yat-sen University
2020-09 PHASE2
NCT03271255 UNKNOWN
Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms
Shenzhen People's Hospital
2018-05-23 PHASE2
NCT04350190 COMPLETED
Nasopharyngeal Carcinoma
Wei Jiang
2021-01-14 PHASE2
NCT04351308 UNKNOWN
Osteosarcoma; Survival; Chemotherapy Effect; Toxicity, Drug
Peking University People's Hospital
2020-05-01 PHASE2
NCT04901754 UNKNOWN
Small Cell Lung Carcinoma
Henan Cancer Hospital
2021-07-14 PHASE2
NCT04523662 UNKNOWN
Hepatocellular Carcinoma
Beijing Tsinghua Chang Gung Hospital
2020-08-30 PHASE2
NCT04006821 UNKNOWN
Gastric Cancer; AFP
China Medical University, China
2019-07-25 PHASE2
NCT04195828 COMPLETED
Advanced Gastric Cancer
Fujian Medical University
2020-06-18 PHASE2
NCT03580395 UNKNOWN
Breast Cancer
Hebei Medical University Fourth Hospital
2017-06-01 PHASE2; PHASE3
NCT04792515 UNKNOWN
Locally Advanced Gastric Cancer
First Affiliated Hospital Xi'an Jiaotong University
2021-01-01 PHASE2
NCT04296370 UNKNOWN
Treatment in HER2-negative Metastatic Breast Cancer Patients With Germline BRCA Mutation
Jiangsu HengRui Medicine Co., Ltd.
2020-07-13 PHASE3
NCT04379739 ACTIVE_NOT_RECRUITING
Non Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
2020-07-26 PHASE2
NCT04586088 UNKNOWN
Nasopharyngeal Carcinoma; Recurrent Nasopharyngeal Carcinoma; Metastatic Nasopharyngeal Carcinoma; Chemotherapy Effect; Immunotherapy; Molecular Targeted Therapy
Sun Yat-sen University
2020-05-05 PHASE2
NCT04415385 UNKNOWN
Pancreatic Cancer
Zhejiang Cancer Hospital
2020-06-01 PHASE2
NCT03878472 COMPLETED
Gastric Cancer
Qilu Hospital of Shandong University
2019-04-01 PHASE2
NCT04665362 UNKNOWN
Advanced/Metastatic Hepatocellular Carcinoma
Liang Peng
2021-01-25 PHASE1
NCT04397770 UNKNOWN
Melanoma
Peking University Cancer Hospital & Institute
2020-05 PHASE2
NCT04440917 UNKNOWN
Head and Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
2020-06-03 PHASE2
NCT03083041 COMPLETED
Carcinoma, Non-Small-Cell Lung
Jiangsu HengRui Medicine Co., Ltd.
2017-03-13 PHASE2
NCT04282278 UNKNOWN
Advanced Solid Tumor
Hebei Medical University Fourth Hospital
2020-07-16 PHASE2
NCT04239443 UNKNOWN
Advanced Non Small Cell Lung Cancer; Uterine Cancer; Soft Tissue Sarcoma
Hunan Cancer Hospital
2019-01-30 PHASE2
NCT04203485 UNKNOWN
PD-L1 Positive Non-small Cell Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.
2020-06-15 PHASE3
NCT03889626 UNKNOWN
Stomach Neoplasms; Gastrointestinal Neoplasms; Stomach Diseases; Digestive System Neoplasms; Capecitabine; Apatinib; Neoplasms; Molecular Mechanisms of Pharmacological Action
Fudan University
2019-03-22 PHASE3
NCT04826406 UNKNOWN
Hepatocellular Carcinoma; Immune Checkpoint Inhibitors
Hunan Cancer Hospital
2021-02-03 PHASE2
NCT03764293 COMPLETED
Locally Advanced or Metastatic and Unresectable HCC
Jiangsu HengRui Medicine Co., Ltd.
2019-06-10 PHASE3
NCT05225844 UNKNOWN
Gastrointestinal Cancer; Immunotherapy; Targeted Therapy
Harbin Medical University
2019-01-01 PHASE2
NCT05025033 COMPLETED
Gastric Cancer
Tianjin Medical University Cancer Institute and Hospital
2019-05-30 PHASE2
NCT04447274 UNKNOWN
Sarcoma
Chinese Academy of Medical Sciences
2020-07-01 PHASE2
NCT04101929 UNKNOWN
Metastatic Pancreatic Cancer
Fudan University
2019-10-01 PHASE2
NCT04035876 UNKNOWN
Hepatocellular Carcinoma; Liver Transplant
Zhejiang University
2019-07-16 PHASE1; PHASE2
NCT04345783 UNKNOWN
Gastric Cancer
Beijing Friendship Hospital
2018-01-01 PHASE2
NCT04506242 UNKNOWN
NSCLC
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2020-09-15 PHASE2
NCT04253873 UNKNOWN
High-grade Gliomas
WuHui
2019-12-16 PHASE2
NCT04985136 TERMINATED
Advanced Hepatocellular Carcinoma (HCC)
Jiangsu HengRui Medicine Co., Ltd.
2021-09-26 PHASE3
NCT04297202 UNKNOWN
Hepatocellular Carcinoma
The First Affiliated Hospital with Nanjing Medical University
2019-12-01 PHASE2
NCT05287360 Completed
Healthy
Elevar Therapeutics
2021-12-30 Phase 1
NCT04201990 UNKNOWN
Lung Cancer
ShiYue Li
2019-12 PHASE1; PHASE2
NCT04121039 UNKNOWN
Gastric Adenocarcinoma; Advanced Cancer
Fujian Cancer Hospital
2019-12 PHASE2
NCT03229096 UNKNOWN
Chemotherapy Effect; Chemotherapeutic Toxicity; Gastric Cancer
Shanghai Zhongshan Hospital
2017-02-01 PHASE2
NCT04204577 UNKNOWN
BCLC Stage B Hepatocellular Carcinoma; BCLC Stage C Hepatocellular Carcinoma
Chinese PLA General Hospital
2019-11-01 PHASE2
NCT03427242 UNKNOWN
Biliary Tract Neoplasms
Fudan University
2017-11-01 PHASE2
NCT03801200 UNKNOWN
NSCLC
Hubei Cancer Hospital
2020-09-10 PHASE2
NCT04428086 COMPLETED
Solid Tumor, Adult
Jiangsu HengRui Medicine Co., Ltd.
2020-07-27 PHASE1
NCT03075462 COMPLETED
Ovarian Cancer; Triple Negative Breast Cancer
Jiangsu HengRui Medicine Co., Ltd.
2017-03-09 PHASE1
NCT03254654 COMPLETED
Advanced Triple-Negative Breast Cancer
Fudan University
2017-08-16 PHASE2
NCT04490421 UNKNOWN
Lung Neoplasm; Small Cell Lung Cancer; PD-1 Inhibitors
Fuzhou General Hospital
2020-08-01 PHASE3
NCT04659785 UNKNOWN
Small Cell Lung Cancer Extensive Stage
Tianjin Medical University Second Hospital
2020-07-01 PHASE1; PHASE2
NCT03612219 UNKNOWN
Nasopharyngeal Carcinoma
Wei Jiang
2018-07-01 PHASE2
NCT04446091 UNKNOWN
Colorectal Cancer
Zhejiang Cancer Hospital
2020-07-01 PHASE1; PHASE2
NCT04068974 UNKNOWN
Recurrent Platinum-resistant Ovarian Cancer
Peking Union Medical College Hospital
2019-10-28 PHASE2
NCT03736863 RECRUITING
Esophageal Cancer
The First Affiliated Hospital of Zhengzhou University
2019-12-05 PHASE2
NCT03609489 UNKNOWN
Biliary Carcinoma
First Affiliated Hospital of Guangxi Medical University
2018-09-10 PHASE2
NCT04411706 UNKNOWN
Hepatocellular Carcinoma
Xin-Hua Xu
2020-06-21 PHASE2
NCT03954756 UNKNOWN
Advanced Gastric Cancer
Henan Cancer Hospital
2019-06-01 PHASE2
NCT03986515 UNKNOWN
Mucosal Melanoma; Advanced Cancer; Apatinib; SHR-1210
Henan Cancer Hospital
2019-06-04 PHASE2
NCT04457180 COMPLETED
Advanced Solid Tumor
Jiangsu HengRui Medicine Co., Ltd.
2020-11-16 PHASE1
NCT04182724 UNKNOWN
Advanced Gastric Cancer
Chinese PLA General Hospital
2019-11-12 PHASE1; PHASE2
NCT03251417 TERMINATED
Esophageal Squamous Cell Carcinoma
Peking University
2017-09-10 PHASE2
NCT04322552 COMPLETED
Advanced Solid Tumor
Jiangsu HengRui Medicine Co., Ltd.
2020-03-12 PHASE1
NCT03092895 COMPLETED
Advanced Primary Liver Cancer; Advanced Biliary Tract Carcinoma
Jiangsu HengRui Medicine Co., Ltd.
2017-04-24 PHASE2
NCT03709953 UNKNOWN
Lung Carcinoma
Guangzhou Institute of Respiratory Disease
2018-10-19 PHASE2
NCT04047017 COMPLETED
Gestational Trophoblastic Disease
Peking Union Medical College Hospital
2019-08-08 PHASE2
NCT03463876 COMPLETED
Hepatocellular Carcinoma
Jiangsu HengRui Medicine Co., Ltd.
2018-03-08 PHASE2
NCT04690231 COMPLETED
Effect of Drug; Toxicity, Drug; Secondary Resistance
Peking University People's Hospital
2020-12-01
NCT04202978 UNKNOWN
Hepatic Metastasis of Colorectal Cancer
Zhongshan Hospital Xiamen University
2020-03-01 PHASE1; PHASE2
NCT03945604 COMPLETED
Triple Negative Breast Cancer
Jiangsu HengRui Medicine Co., Ltd.
2019-06-04 PHASE1
NCT04682249 WITHDRAWN
ICC
Sun Yat-sen University
2020-12-01 PHASE2
NCT04348032 UNKNOWN
Platinum-resistant Recurrent Ovarian Cancer
Chinese Academy of Medical Sciences
2018-03-22 PHASE2
NCT04414852 UNKNOWN
Subjects With Impaired Renal Function and Healthy Subjects
Jiangsu HengRui Medicine Co., Ltd.
2020-06-05 PHASE1
NCT04000295 UNKNOWN
Ovarian Cancer
Jiangsu HengRui Medicine Co., Ltd.
2019-08-16 PHASE3
NCT03787251 WITHDRAWN
Esophageal Neoplasms
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
2019-01-01 PHASE2
NCT03154983 UNKNOWN
Metastatic Gastric Cancer
Zhou Fuxiang
2017-05-20 PHASE2
NCT03428022 UNKNOWN
NSCLC; Apatinib; EGFR-TKI
Shenzhen People's Hospital
2017-12-01 PHASE3
NCT03389256 UNKNOWN
Lung Diseases; Neoplasms; Respiratory Tract Diseases; Thoracic Neoplasms; Non-Small-Cell Lung
Sichuan Cancer Hospital and Research Institute
2018-12-30 PHASE2
NCT03355612 UNKNOWN
Gastric Carcinoma
Tianjin Medical University Cancer Institute and Hospital
2017-12-20 PHASE3
NCT04174339 UNKNOWN
Advanced Gastric Adenocarcinoma
Fujian Cancer Hospital
2019-12-10
NCT04089657 UNKNOWN
Advanced Metastatic Gastric Cancer
Fujian Cancer Hospital
2019-12-01 PHASE2
NCT03775928 UNKNOWN
Triple-negative Breast Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2018-12-18 PHASE2
NCT03411967 UNKNOWN
Lung Cancer
Zigong No.1 Peoples Hospital
2018-02-01 PHASE2
NCT04383977 UNKNOWN
Ovarian Cancer
Jiangsu HengRui Medicine Co., Ltd.
2020-05 PHASE2
NCT03811054 UNKNOWN
Non Small Cell Lung Cancer
Beijing Chest Hospital
2018-12-01 PHASE2
NCT04128800 UNKNOWN
Small Cell Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
2019-10 PHASE2
NCT03475589 UNKNOWN
Stage IV Cancer
Sun Yat-sen University
2018-02-26 PHASE4
NCT03472365 COMPLETED
Gastric Cancer; GastroEsophageal Cancer
Jiangsu HengRui Medicine Co., Ltd.
2018-04-02 PHASE2
NCT03758677 UNKNOWN
Non Small Cell Lung Cancer
The First Hospital of Jilin University
2020-08-01 PHASE2
NCT04393506 COMPLETED
Oral Cancer; VEGFR2 Inhibitor; Programmed Cell Death 1 Inhibitor; Inductive Therapy
Shanghai Jiao Tong University School of Medicine
2020-04-23 PHASE1
NCT04165174 UNKNOWN
HCC
Huazhong University of Science and Technology
2019-12 PHASE2
NCT03396211 COMPLETED
Cancer
Elevar Therapeutics
2017-12-22 PHASE1
NCT03267654 UNKNOWN
Non-small-cell Lung Cancer
Qilu Pharmaceutical Co., Ltd.
2017-10-12 PHASE2
NCT03743428 Suspended
Colorectal Neoplasms
Shenzhen People''s Hospital
2020-10-22 Not Applicable
NCT04517357 Unknown status
Relapsed Ovarian Cancer
Jiangsu HengRui Medicine Co. Ltd.
2020-10-16 Phase 2
NCT03397199 UNKNOWN
Colorectal Cancer
Henan Cancer Hospital
2018-01-09 PHASE2
NCT03267121 COMPLETED
Head and Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
2017-10-01 PHASE2
NCT04067986 UNKNOWN
Colorectal Cancer Recurrent
Zhongshan Hospital Xiamen University
2019-08-20 PHASE1; PHASE2
NCT02878057 COMPLETED
Breast Cancer
Peking University Cancer Hospital & Institute
2016-05 PHASE2
NCT03942068 UNKNOWN
Ovarian Cancer
Henan Cancer Hospital
2019-09-01 PHASE2
NCT03258034 UNKNOWN
Gastric Cancer
The First Affiliated Hospital of Zhejiang Chinese Medical University
2017-08-24 PHASE2
NCT03702491 UNKNOWN
Gallbladder Carcinoma
Eastern Hepatobiliary Surgery Hospital
2018-08-10 PHASE2
NCT03377842 UNKNOWN
Colorectal Cancer; Neoadjuvant Therapy
Sichuan Provincial People's Hospital
2018-01-31 PHASE2
NCT03262545 UNKNOWN
Angiogenesis Inhibitors,Ovarian Neoplasms
Sichuan Cancer Hospital and Research Institute
2017-08-27 PHASE2
NCT03190239 WITHDRAWN
Advanced Non-squamous Non-small-cell Lung Cancer
Xinqiao Hospital of Chongqing
2017-07-15 PHASE2
NCT04341090 COMPLETED
Healthy Subjects
Jiangsu HengRui Medicine Co., Ltd.
2020-05-13 PHASE1
NCT03213587 UNKNOWN
Nasopharyngeal Carcinoma
Zhejiang Cancer Hospital
2017-07-01 PHASE2
NCT03587129 TERMINATED
Ovarian Cancer
First Affiliated Hospital of Harbin Medical University
2018-07-10 PHASE2
NCT03913182 UNKNOWN
Esophageal Squamous Cell Carcinoma; Apatinib; Recurrence; Metastasis
Shanghai Chest Hospital
2019-04-02 PHASE2
NCT02426034 COMPLETED
Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
Jiangsu HengRui Medicine Co., Ltd.
2015-05-15 PHASE4
NCT03816553 COMPLETED
Recurrent Cervical Carcinoma; Metastatic Cervical Cancer
Sun Yat-sen University
2019-01-19 PHASE2
NCT03955354 UNKNOWN
Melanoma
Peking University Cancer Hospital & Institute
2019-03-05 PHASE2
NCT04180007 UNKNOWN
Thyroid; Metastasis; Apatinib
Nanjing First Hospital, Nanjing Medical University
2019-04-10 PHASE2
NCT03180476 COMPLETED
Nasopharyngeal Neoplasms
Sichuan Cancer Hospital and Research Institute
2017-04-01 PHASE2
NCT03868852 UNKNOWN
Childhood Rhabdomyosarcoma
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
2019-01-01 PHASE1; PHASE2
NCT03701022 UNKNOWN
NK/T-cell Lymphoma
Peking University
2018-10-20 PHASE2
NCT03603756 UNKNOWN
Esophageal Squamous Cell Carcinoma
Chinese Academy of Medical Sciences
2018-07-31 PHASE2
NCT03048877 UNKNOWN
Differentiated Thyroid Cancer
Peking Union Medical College Hospital
2016-12 PHASE3
NCT03349827 TERMINATED
Peritoneal Metastases From Gastric Cancer
Wuhan University
2018-01-05
NCT03662035 UNKNOWN
Advanced Pancreatic Cancer
Changzhou No.2 People's Hospital
2018-09-15 PHASE2
NCT03857763 UNKNOWN
Esophageal Squamous Cell Carcinoma
Hebei Medical University Fourth Hospital
2019-03-01 PHASE2
NCT03654612 UNKNOWN
Head and Neck Cancer
China International Medical Foundation
2018-10-16 PHASE1; PHASE2
NCT03116555 UNKNOWN
Metastatic Gastric Adenocarcinoma
China Medical University, China
2017-04-05 PHASE2
NCT03412994 UNKNOWN
Colorectal Neoplasms
Liqiang Zhong
2018-02-28 PHASE2
NCT02731352 COMPLETED
Thyroid Cancer
Peking Union Medical College Hospital
2016-03-11 PHASE2
NCT03792503 WITHDRAWN
Advanced Non-squamous Non-small-cell Lung Cancer
Xinqiao Hospital of Chongqing
2019-02 PHASE4
NCT04152681 UNKNOWN
Radiation Injuries
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2019-10-17 PHASE2
NCT03144843 UNKNOWN
Gastric Cancer
Sun Yat-sen University
2017-01-13 PHASE2
NCT03793725 UNKNOWN
Hepatocellular Carcinoma
Yanqiao Zhang
2019-01-30 PHASE2
NCT03261791 UNKNOWN
Carcinoma, Hepatocellular
Shanghai Zhongshan Hospital
2017-07-20 PHASE2
NCT03598348 UNKNOWN
Gastric Cancer
Huazhong University of Science and Technology
2018-01-16 PHASE3
NCT04260113 COMPLETED
Efficacy; Toxicity, Drug
Peking University People's Hospital
2019-10-01
NCT03631862 UNKNOWN
Newly Diagnosed Peripheral T-cell Lymphoma
Zhengzhou University
2018-09-01 PHASE4
NCT04126993 UNKNOWN
Sarcoma
Tianjin Medical University Cancer Institute and Hospital
2019-06-01 PHASE2
NCT04126811 UNKNOWN
Soft Tissue Sarcoma
Tianjin Medical University Cancer Institute and Hospital
2019-06-01 PHASE2
NCT03394287 COMPLETED
Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2018-01-10 PHASE2
NCT03650738 UNKNOWN
Systematic Review of the pCR Rate of Apatinib Combined With Albumin Paclitaxel and Carboplatin Regimen for Neoadjuvant Therapy of Triple-negative Breast Cancer
The First Affiliated Hospital with Nanjing Medical University
2018-09-01 PHASE2
NCT03539172 UNKNOWN
Soft Tissue and Bone Tumor; Head and Neck Cancer; Sarcoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
2018-06-01 PHASE2
NCT03547375 UNKNOWN
Ovarian Cancer
Anhui Provincial Hospital
2018-06-01 PHASE2
NCT03645200 UNKNOWN
Advanced Cancer
Tianjin Medical University Second Hospital
2019-07-01 PHASE1
NCT03546855 UNKNOWN
Cervical Cancer
Anhui Provincial Hospital
2018-06-01 PHASE2
NCT03104283 COMPLETED
Gastric Cancer
Affiliated Hospital of Qinghai University
2017-06-05 PHASE2
NCT03912857 UNKNOWN
Metastatic Colorectal Cancer
Sun Yat-sen University
2018-12-01 PHASE2
NCT02976896 COMPLETED
Esophageal Squamous Cell Carcinoma
Yuhong Li
2016-08 PHASE2
NCT03788174 UNKNOWN
Gastric Adenocarcinoma
Fujian Cancer Hospital
2019-02-01 PHASE2
NCT03029013 UNKNOWN
Cervical Cancer
Third Military Medical University
2017-01
NCT02733107 UNKNOWN
Non-small Cell Lung Cancer
Third Military Medical University
2016-03 PHASE2
NCT03349866 UNKNOWN
Gastroesophageal Junction Adenocarcinoma
Hebei Medical University
2017-11-30 PHASE2
NCT03192735 UNKNOWN
Apatinib Combined; SOX; Neoadjuvant Therapy; Locally Advanced Gastric Cancer
Chang-Ming Huang, Prof.
2017-09-01 PHASE2
NCT03389087 UNKNOWN
Small Cell Lung Cancer
Henan Cancer Hospital
2017-11-29 PHASE2
NCT03718624 UNKNOWN
Gastric Cancer With Positive Exfoliative Cancer Cells
Hebei Medical University
2018-10-30 PHASE2
NCT03547804 COMPLETED
Small-cell Lung Cancer
The First Hospital of Jilin University
2018-05-31 PHASE2
NCT03359018 COMPLETED
Progression-free Survival; Overall Survival; Clinical Benefit Rate; Toxicity
Peking University People's Hospital
2018-01-01 PHASE2
NCT03334591 UNKNOWN
Two Different Treatment Methods
Anhui Provincial Hospital
2017-10-01 PHASE2
NCT03707639 UNKNOWN
Gastric Adenocarcinoma
Fujian Cancer Hospital
2018-11 PHASE2
NCT02943252 UNKNOWN
Head and Neck Neoplasms
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2016-10 PHASE2
NCT03671265 UNKNOWN
Esophageal Cancer
Tianjin Medical University Cancer Institute and Hospital
2018-09-17
NCT03407976 TERMINATED
Advanced Malignancies; Urothelial Carcinoma; MSI-H or dMMR Solid Tumors; Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
University of Utah
2018-06-19 PHASE1
NCT03634059 UNKNOWN
NSCLC
Hebei Medical University Fourth Hospital
2018-08-15
NCT03651219 UNKNOWN
Small Cell Lung Cancer
Beijing Chest Hospital
2018-09-08 PHASE3
NCT03219593 UNKNOWN
Gastric Cancer; Apatinib; Biomarker
The First Affiliated Hospital of Bengbu Medical University
2017-09-07 PHASE2
NCT02942693 UNKNOWN
Adenoid Cystic Carcinoma
Shanghai Proton and Heavy Ion Center
2016-11 PHASE2
NCT03950141 UNKNOWN
HER-2 Negatived Gastric Cancer
Beijing Hospital
2017-07-01 PHASE2
NCT03300765 UNKNOWN
Thyroid Cancer
Xiayun He, MD
2017-07-01 PHASE2
NCT03594682 UNKNOWN
NSCLC Stage IV; NSCLC Stage IIIB
Beijing Chest Hospital
2018-08
NCT03243643 UNKNOWN
Advanced Cancer
Jiangsu Hansoh Pharmaceutical Co., Ltd.
2017-08-08 PHASE1
NCT03104335 WITHDRAWN
Soft Tissue Sarcoma Adult; Advanced Cancer
Peking University People's Hospital
2017-04-01 PHASE2
NCT03190616 COMPLETED
Colorectal Neoplasms
The First Affiliated Hospital with Nanjing Medical University
2017-07-01 PHASE2
NCT03403452 UNKNOWN
Colorectal Cancer
Fudan University
2018-01-01 PHASE2
NCT03510416 UNKNOWN
Hepatocellular Carcinoma Refractory to Transcatheter Arterial Chemoembolization
Shanghai Zhongshan Hospital
2018-05-01 PHASE2
NCT03285906 UNKNOWN
Esophagus Cancer, Stage III; Esophageal Gastric Cardia Type Metaplasia; Esophagus Cancer, Stage IV
Tianjin Medical University Cancer Institute and Hospital
2017-03-01 PHASE2; PHASE3
NCT02704767 UNKNOWN
Lung Cancer
First Affiliated Hospital of Kunming Medical University
2016-06 PHASE2
NCT03725423 UNKNOWN
Lung Squamous Cell Carcinoma
Xuzhou Central Hospital
2018-10 PHASE4
NCT03050411 UNKNOWN
Nonsmall Cell Lung Cancer
Peking University Third Hospital
2016-05 PHASE1
NCT03535961 COMPLETED
Breast Cancer
Chinese Academy of Medical Sciences
2017-05-01 PHASE2
NCT04338438 COMPLETED
Gastric Cancer
Beijing Friendship Hospital
2015-05-01 PHASE2
NCT03130270 UNKNOWN
Nasopharyngeal Carcinoma
Guilin Medical University, China
2017-01-01 PHASE2
NCT03127319 UNKNOWN
Non-squamous Non-small Cell Lung Cancer
Affiliated Hospital of Hebei University
2017-07-03 PHASE2
NCT03256721 TERMINATED
Nonsmall Cell Lung Cancer
Fuzhou General Hospital
2017-08-16 PHASE2
NCT03114085 UNKNOWN
Hepatocellular Carcinoma
First Affiliated Hospital of Guangxi Medical University
2017-05-20 PHASE2
NCT03274011 COMPLETED
Esophageal Neoplasms
Fudan University
2017-07-01 PHASE2
NCT03457467 UNKNOWN
Breast Cancer
Yan Li
2018-03-15 PHASE2
NCT03144856 UNKNOWN
Biliary Tract Cancer
Sun Yat-sen University
2017-02-22 PHASE2
NCT03129698 UNKNOWN
Apatinib in Maintenance Treatment
Junling Li
2017-04-11 PHASE2
NCT03722875 UNKNOWN
Hepatocellular Carcinoma
Shanghai Zhongshan Hospital
2018-12-01
NCT02980809 UNKNOWN
Small Cell Lung Cancer
First Hospitals affiliated to the China PLA General Hospital
2017-03 PHASE2
NCT03042611 COMPLETED
Gastric Cancer; Gastric Adenocarcinoma
Elevar Therapeutics
2017-03-14 PHASE3
NCT03376958 COMPLETED
Relapsed and Refractory; Diffuse Large B Cell Lymphoma
Zhengzhou University
2017-01-01 PHASE4
NCT02596256 UNKNOWN
Gastric Cancer
Chinese PLA General Hospital
2016-04 PHASE2
NCT03422445 UNKNOWN
Advanced Melanoma
Peking University Cancer Hospital & Institute
2018-01-08 PHASE2
NCT03167385 UNKNOWN
Differentiated Thyroid Carcinoma
Tianjin Medical University Cancer Institute and Hospital
2017-03-22 PHASE2
NCT03255811 UNKNOWN
Advanced Gastric Cancer
DongMa
2017-03-25
NCT03224221 UNKNOWN
Esophageal Squamous Cell Carcinoma
The First Affiliated Hospital of Anhui Medical University
2017-03-23 PHASE2
NCT03344614 UNKNOWN
Colorectal Cancer
Chinese PLA General Hospital
2017-07-01 PHASE2
NCT03416231 UNKNOWN
NSCLC
Affiliated Hospital of North Sichuan Medical College
2016-11-30 PHASE2
NCT03356600 UNKNOWN
Brain Metastases
Shanxi Province Cancer Hospital
2017-12 PHASE2
NCT03511703 UNKNOWN
Hepatocellular Carcinoma
Guangxi Medical University
2018-05-01 PHASE2
NCT03244774 UNKNOWN
Gastric Adenocarcinoma
Fujian Cancer Hospital
2018-01-01 PHASE1
NCT03520257 UNKNOWN
Hepatocellular Carcinoma
Guangxi Medical University
2018-05-01 PHASE2
NCT03193424 UNKNOWN
Advanced Esophageal Squamous Carcinoma
The First Affiliated Hospital of Zhengzhou University
2016-10 PHASE2
NCT03129256 COMPLETED
Non-small Cell Lung Cancer
Changzhou Cancer Hospital of Soochow University
2016-12-01 PHASE2
NCT02764268 COMPLETED
Gastric Cancer
Jiangsu HengRui Medicine Co., Ltd.
2016-11-02
NCT03393507 UNKNOWN
Ovarian Cancer; Chemotherapeutic Toxicity
The People's Hospital of Leshan
2017-08-01 PHASE2
NCT02727309 UNKNOWN
Hepatocellular Carcinoma
Peking University Cancer Hospital & Institute
2015-10 PHASE1; PHASE2
NCT03542422 UNKNOWN
Advanced Esophagus Cancer
Affiliated Hospital of North Sichuan Medical College
2018-06-30 PHASE2
NCT02645864 COMPLETED
Esophageal Squamous Cell Carcinoma
Peking University
2016-01 PHASE1
NCT02989259 UNKNOWN
Head and Neck Neoplasms
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2016-12 PHASE2
NCT03428425 UNKNOWN
Gastric Cancer
Hebei Medical University
2018-02 PHASE2
NCT03135977 UNKNOWN
Extensive-stage Small Cell Lung Cancer; Lung Cancer
Sichuan Cancer Hospital and Research Institute
2017-03-01 PHASE2
NCT03652857 COMPLETED
Advanced Non Small Cell Lung Cancer
Yongchang Zhang
2017-01-01 PHASE2
NCT02874651 TERMINATED
Nasopharyngeal Neoplasms
Sun Yat-sen University
2016-10 PHASE2
NCT02945852 COMPLETED
Small Cell Lung Cancer
Fan Yun, MD
2016-10 PHASE2
NCT03121846 UNKNOWN
Soft Tissue Sarcoma, Adult, Stage II
Tianjin Medical University Cancer Institute and Hospital
2017-05-01 PHASE2
NCT03086785 UNKNOWN
Breast Cancer Metastatic
Hebei Medical University Fourth Hospital
2016-11-24 PHASE2
NCT03521219 UNKNOWN
Intrahepatic Cholangiocarcinoma
The First Affiliated Hospital of Zhengzhou University
2018-02-07 PHASE2
NCT03298074 UNKNOWN
Ovarian Cancer
Yang Zhijun
2017-10 PHASE2
NCT02942329 UNKNOWN
Gastric Cancer; Hepatocellular Carcinoma
The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
2016-10 PHASE1; PHASE2
NCT02875457 UNKNOWN
Small Cell Lung Cancer
Third Military Medical University
2016-09 PHASE3
NCT03271073 UNKNOWN
Gastric Cancer
Beijing Friendship Hospital
2016-02-01 PHASE2
NCT03096184 UNKNOWN
Head and Neck Squamous Cell Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
2016-12-23 PHASE2
NCT03030937 UNKNOWN
Advanced Gastric Cancer Adenocarcinoma of Esophagogastric Junction
Fujian Cancer Hospital
2017-02-01 PHASE2
NCT03348098 UNKNOWN
Triple Negative Breast Cancer
Tianjin Medical University Cancer Institute and Hospital
2017-09-06 PHASE2
NCT02848794 UNKNOWN
High-grade Glioma
The First People's Hospital of Lianyungang
2016-07 PHASE1; PHASE2
NCT02510469 UNKNOWN
Gastric Cancer
Hebei Medical University
2015-07 PHASE2; PHASE3
NCT03424291 UNKNOWN
Head and Neck Squamous Cell Carcinoma
Henan Cancer Hospital
2017-07-05 PHASE2
NCT03199677 UNKNOWN
Refractory Cancer
Chinese Academy of Medical Sciences
2017-07-01 PHASE2
NCT03066557 UNKNOWN
Hepatocellular Carcinoma
Jiangsu Cancer Institute & Hospital
2017-03-15
NCT03376737 UNKNOWN
Lung Adenocarcinoma
Henan Cancer Hospital
2017-10-12 PHASE2
NCT02995187 UNKNOWN
Small Cell Lung Cancer
Chinese Academy of Medical Sciences
2016-12 PHASE2
NCT03245307 UNKNOWN
Cytochrome P450 Interaction
Jiangsu HengRui Medicine Co., Ltd.
2017-08-22 PHASE1
NCT03210064 UNKNOWN
Metastatic Colorectal Cancer
Hui ting Xu,MD
2017-05-04 PHASE2
NCT03026881 UNKNOWN
Recurrent and Metastatic Gastric Cancer
Jiangsu HengRui Medicine Co., Ltd.
2017-01 PHASE1
NCT02697838 UNKNOWN
Malignant Neoplasm of Stomach Stage II
Fujian Cancer Hospital
2016-08-01 PHASE2
NCT03064243 UNKNOWN
Soft Tissue Sarcoma
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
2017-03-01 PHASE2
NCT02702323 UNKNOWN
Hepatocellular Carcinoma; Pulmonary Metastasis
Zhejiang Cancer Hospital
2016-03 PHASE2; PHASE3
NCT03132025 UNKNOWN
Metastatic Colorectal Cancer
Yanqiao Zhang
2017-04-30 PHASE2
NCT03276156 UNKNOWN
Gastric Cancer
Zhejiang Cancer Hospital
2016-02-23 PHASE1
NCT03384511 COMPLETED
Malignancies; Stomach Cancer; Non-small Cell Lung Cancer; Esophageal Cancer; Breast Cancer; Ovary Cancer; Cervical Cancer
Shandong Cancer Hospital and Institute
2016-09-30 PHASE4
NCT02768415 UNKNOWN
Breast Cancer
Chinese Academy of Medical Sciences
2016-06 PHASE2
NCT02867956 COMPLETED
Ovarian Cancer
Sun Yat-sen University
2016-08-10 PHASE2
NCT02863367 UNKNOWN
Metastatic Pancreatic Cancer
Tianjin Medical University Cancer Institute and Hospital
2016-08 PHASE2
NCT02780778 UNKNOWN
Non-small Cell Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
2016-05 PHASE2; PHASE3
NCT03046979 UNKNOWN
Hepatocellular Carcinoma
Tianjin Medical University Cancer Institute and Hospital
2016-12 PHASE2
NCT03071042 UNKNOWN
Metastatic Gastric Adenocarcinoma
Sir Run Run Shaw Hospital
2015-10 PHASE1
NCT02829385 UNKNOWN
Colorectal Neoplasms
Shoucheng Ma
2016-06 PHASE2
NCT02775370 UNKNOWN
Adenoid Cystic Carcinoma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
2016-05 PHASE2
NCT02509806 UNKNOWN
Gastric Cancer
Hebei Medical University
2015-07 PHASE2; PHASE3
NCT02726854 UNKNOWN
Pancreatic Neoplasms
First Affiliated Hospital Xi'an Jiaotong University
2016-04 PHASE2
NCT03320629 TERMINATED
Refractory or Metastatic Esophageal Squamous Cell Carcinoma
Hebei Medical University Fourth Hospital
2017-11-01 PHASE2
NCT02974933 UNKNOWN
Nonsmall Cell Lung Cancer
Wuling Ou
2016-11 PHASE2
NCT03163381 UNKNOWN
Osteosarcoma, Advanced
Henan Cancer Hospital
2017-04-11 PHASE2
NCT02772029 UNKNOWN
Hepatocellular Carcinoma
The First Affiliated Hospital of Zhengzhou University
2016-05 PHASE1; PHASE2
NCT02332512 UNKNOWN
Carcinoma, Non-Small-Cell Lung
Jiangsu HengRui Medicine Co., Ltd.
2015-01 PHASE3
NCT02776527 UNKNOWN
Gastric Cancer
Tianjin Medical University Cancer Institute and Hospital
2016-04 PHASE4
NCT02836171 COMPLETED
Neoplasms
Jiangsu HengRui Medicine Co., Ltd.
2016-07 PHASE1
NCT02836821 COMPLETED
Neoplasms
Jiangsu HengRui Medicine Co., Ltd.
2016-05 PHASE1
NCT02998242 COMPLETED
Quality of Life
Sichuan Provincial People's Hospital
2016-05-10
NCT03660761 COMPLETED
Efficacy and Safety
Rongjie Tao
2016-03-03 PHASE2
NCT02544737 UNKNOWN
Esophageal Cancer; Metastatic Esophageal Cancer; Apatinib
Hangzhou Cancer Hospital
2015-09 PHASE2
NCT02774200 UNKNOWN
Metastatic Renal Cell Carcinoma
Tianjin Medical University Cancer Institute and Hospital
2016-05 PHASE2
NCT02540824 UNKNOWN
Non-small Cell Lung Cancer
Tongji University
2015-01 PHASE2
NCT02711969 COMPLETED
Gastric Cancer
Bukwang Pharmaceutical
2016-03 PHASE1
NCT02683655 UNKNOWN
Esophageal Cancer
Huai'an First People's Hospital
2015-08 PHASE2
NCT02691871 UNKNOWN
Lung Adenocarcinoma
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
2016-02 PHASE1
NCT02537171 UNKNOWN
Gastric Cancer
The Affiliated Hospital of the Chinese Academy of Military Medical Sciences
2015-07 PHASE3
NCT02525237 UNKNOWN
Gastric Cancer
Qingdao Municipal Hospital
2015-08 PHASE2
NCT01531777 COMPLETED
Colorectal Cancer
Jiangsu HengRui Medicine Co., Ltd.
2011-04 PHASE2
NCT01176669 COMPLETED
Metastatic Breast Cancer
Fudan University
2010-06 PHASE2
NCT01192971 COMPLETED
Advanced Hepatocellular Carcinoma
Jiangsu HengRui Medicine Co., Ltd.
2010-06 PHASE2
NCT01512745 COMPLETED
Advanced or Metastatic Gastric Cancer
Jiangsu HengRui Medicine Co., Ltd.
2011-01 PHASE3
NCT01287962 UNKNOWN
Non-small Cell Lung Cancer
Sun Yat-sen University
2011-04 PHASE3
NCT01653561 COMPLETED
Breast Neoplasms
Fudan University
2011-11 PHASE2
NCT01270386 COMPLETED
Non-Small-Cell Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.
2010-03 PHASE2
NCT00970138 COMPLETED
Gastric Carcinoma
Fudan University
2009-06 PHASE2; PHASE3
NCT00633490 UNKNOWN
Tumor
Fudan University
2007-07 PHASE1

(data from https://clinicaltrials.gov, updated on 2026-01-28)

Check the Apatinib (YN968D1) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Apatinib selectively binds to and inhibits VEGFR-2, alongside c-Kit and Ret receptor tyrosine kinases, thereby blocking downstream autophosphorylation and angiogenic signaling cascades. This pathway inhibition suppresses endothelial cell proliferation, induces both autophagy and apoptosis, and ultimately disrupts tumor neovascularization to suppress progression in clinical trial indications such as hepatocellular carcinoma, gastric cancer, and advanced breast cancer.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.