Home Biosimilar Antibodies Immunology & Inflammation CD markers Anti-TREM1 / CD354 (PY159)
For research use only. Not for use in humans.

Anti-TREM1 / CD354 (PY159)

Synonyms: Protectin， MIRL

Anti-TREM1 / CD354 (PY159) is a humanized agonistic monoclonal antibody targeting triggering receptor expressed on myeloid cells 1 (TREM1), with potential immunomodulating and antineoplastic activities. MW: 143.66 kD.

Anti-TREM1 / CD354 (PY159)

Quality Control

Batch: A275401 Purity: 99% Protein concentration: 9.77mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation CD38 CD45 CD39 CD88 CD73 Others
RBN013209 0
MK-0159 0
CD38 inhibitor 1 (compound 78c) 7
AB680 1
NQ301 1 TXA2 receptor
SodiuM Metatungstate 3
PMX-53 3
LY-3475070 2
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Anti-TREM1 / CD354 (PY159) is a humanized agonistic monoclonal antibody targeting triggering receptor expressed on myeloid cells 1 (TREM1), with potential immunomodulating and antineoplastic activities. MW: 143.66 kD.
References

Product Details

Molecular Weight 143.66
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04682431 TERMINATED Drug: PY159 Single agent dose level 1|Drug: PY159 Single age Advanced Solid Tumor; Gynecologic Cancer; Breast Cancer; Colorectal Cancer; Gastric Adenocarcinoma; Lung Adenocarcinoma; Pancreatic Cancer; Head and Neck Cancer Ikena Oncology 2020-11-10 PHASE1

(data from https://clinicaltrials.gov, updated on 2024-03-22)

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