Amiodarone HCl Clinical Trials

Size	Price	Qty
50mg	USD 147
1g	USD 670

Clinical Trials

Amiodarone hydrochloride has been evaluated across numerous clinical trials spanning Phase 1 to Phase 4, primarily addressing cardiac arrhythmias—including atrial fibrillation, supraventricular tachycardia, and atrial flutter—alongside coronary artery disease and esophageal carcinoma. Sponsored by pharmaceutical leaders like Sanofi as well as academic institutions such as Massachusetts General Hospital and the OHSU Knight Cancer Institute, these studies range in status from completed to actively recruiting. Overall, this research assesses its prophylactic and therapeutic utility to optimize post-surgical heart rhythm management and improve perioperative outcomes.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03868150	RECRUITING	Postoperative Atrial Fibrillation	Stanford University	2017-03-01	PHASE4
NCT05841056	RECRUITING	Atrial Fibrillation New Onset	Population Health Research Institute	2024-06-13	PHASE3
NCT06322017	RECRUITING	Atrial Fibrillation	Nantes University Hospital	2024-04-09
NCT07519161	NOT_YET_RECRUITING	Atrial Fibrillation	Shanghai East Hospital	2026-04-07
NCT07405671	NOT_YET_RECRUITING	Atrial Fibrillation (AF); Coronary Artery Disease	Universitaire Ziekenhuizen KU Leuven	2026-09	PHASE4
NCT04748991	NOT_YET_RECRUITING	Atrial Fibrillation; Post-cardiac Surgery	University of Calgary	2026-09	PHASE3
NCT05543278	NOT_YET_RECRUITING	Surgery, Cardiac; Atrial Fibrillation	Massachusetts General Hospital	2027-01	PHASE4
NCT06680869	RECRUITING	Cardiac Arrest	Oregon Health and Science University	2025-01-01	PHASE3
NCT06669299	RECRUITING	Ventricular Tachycardia (VT)	IRCCS Ospedale San Raffaele	2025-06-12
NCT07273994	RECRUITING	Persistent Atrial Fibrillation	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	2025-11-01	PHASE4
NCT06067438	RECRUITING	Atrial Fibrillation; Esophageal Carcinoma	OHSU Knight Cancer Institute	2024-06-21	PHASE2
NCT06063538	RECRUITING	Atrial Fibrillation; Post-Op Complication	University of Chicago	2024-02-15	EARLY_PHASE1
NCT07487714	ENROLLING_BY_INVITATION	Paroxysmal AF; Treatment Decisions; Therapeutic Drug Monitoring (TDM)	Tomsk National Research Medical Center of the Russian Academy of Sciences	2026-01-12	PHASE4
NCT02750319	ACTIVE_NOT_RECRUITING	Thoracic Surgery; Atrial Fibrillation in High Risk Patients	Memorial Sloan Kettering Cancer Center	2016-04	PHASE3
NCT01422148	NOT_YET_RECRUITING	Atrial Fibrillation	Baystate Medical Center	2025-07	PHASE2
NCT06722196	RECRUITING	Atrial Fibrillation (AF)	Jilin Heart Hospital	2025-02-15	PHASE3
NCT06835491	RECRUITING	Ventricular Arrhythmias and Cardiac Arrest	Versailles Hospital	2025-11-06	PHASE3
NCT06645249	NOT_YET_RECRUITING	Atrial Fibrillation (AF)	Institut Investigacio Sanitaria Pere Virgili	2024-12-10	PHASE4
NCT06742866	NOT_YET_RECRUITING	Atrial Fibrillation (AF)	Shanghai Chest Hospital	2024-12-16
NCT07181265	NOT_YET_RECRUITING	Autosomal Dominant Polycystic Kidney Disease (ADPKD)	Jemincare	2025-10-30	PHASE1
NCT04594746	TERMINATED	Atrial Fibrillation	University of Calgary	2022-02-03	PHASE4
NCT05549752	RECRUITING	Atrial Fibrillation Paroxysmal; Coronary Artery Disease Without Residual Ischemia	Hippocration General Hospital	2023-03-24	PHASE3
NCT06730828	RECRUITING	Atrial Fibrillation, Postoperative	Helios Cardio Inc.	2024-12-16	PHASE1; PHASE2
NCT05287191	UNKNOWN	Atrial Fibrillation New Onset	Sunnybrook Health Sciences Centre	2022-01-05	PHASE3
NCT04942834	COMPLETED	Atrial Fibrillation, Persistent; Arrhythmias, Cardiac	Ruijin Hospital	2021-10-01
NCT05169866	UNKNOWN	New Onset Atrial Fibrillation; Complications; Cardiac, Postoperative	Beijing Anzhen Hospital	2022-05-29	PHASE3
NCT06657404	RECRUITING	Atrial Fibrillation (AF)	Yumei Xue	2024-10-23
NCT06262932	COMPLETED	Atrial Fibrillation	Police General Hospital, Thailand	2024-05-01	PHASE4
NCT06067438	Not yet recruiting	Atrial Fibrillation\|Esophageal Carcinoma	OHSU Knight Cancer Institute	2024-05-01	Phase 2
NCT05841056	Not yet recruiting	Atrial Fibrillation New Onset	Population Health Research Institute	2024-05-31	Phase 3
NCT05852704	Recruiting	Chronic Coronary Syndrome\|Atrial Fibrillation	Region Örebro County\|Odense University Hospital\|Aarhus University Hospital\|Örebro University Sweden\|Sahlgrenska University Hospital Sweden\|Göteborg University\|University of Leeds\|Skane University Hospital\|London School of Hygiene and Tropical Medicine\|St. Anne''s University Hospital Brno Czech Republic\|Mount Sinai Hospital New York\|University Hospital Linkoeping\|Icahn School of Medicine at Mount Sinai	2024-04-04	Phase 3
NCT04392921	UNKNOWN	Atrial Fibrillation	Ottawa Hospital Research Institute	2022-03-07
NCT05681182	COMPLETED	Post Operative Atrial Fibrillation	WakeMed Health and Hospitals	2023-01-20	PHASE4
NCT05543278	Not yet recruiting	Surgery Cardiac\|Atrial Fibrillation	Massachusetts General Hospital	2024-02-01	Phase 4
NCT05445297	COMPLETED	Atrial Fibrillation Paroxysmal	National Medical Research Center for Cardiology, Ministry of Health of Russian Federation	2022-01-26	PHASE4
NCT05125042	UNKNOWN	Persistent Atrial Fibrillation	Shanghai Chest Hospital	2021-12-01
NCT05641883	UNKNOWN	POAF; Atrial Fibrillation	Saint Alphonsus Regional Medical Center	2023-01-01
NCT04234906	UNKNOWN	Cardiac; Dysrhythmia, Postoperative; Congenital Heart Surgery	Jeffrey Moak	2023-01	PHASE4
NCT04845607	UNKNOWN	Cardiac Arrest; Ventricular Arrythmia	Won Young Kim	2021-04-01	PHASE3
NCT05004077	TERMINATED	Atrial Fibrillation	Kevin W Hatton, MD, PhD	2021-11-02	PHASE4
NCT01722942	UNKNOWN	Chagas Cardiomyopathy; Non-sustained Ventricular Tachycardia; At Least 10 Points in Rassi Risk Score for Death	InCor Heart Institute	2014-10-06
NCT03029169	COMPLETED	Supraventricular Arrhythmia; Septic Shock	Charles University, Czech Republic	2017-10-23	PHASE4
NCT05950971	TERMINATED	Atrial Fibrillation New Onset; Atrial Fibrillation Paroxysmal	Seoul National University Hospital	2021-07-01
NCT03991754	UNKNOWN	Atrial Fibrillation New Onset	Luis Nombela Franco	2019-06-30	PHASE3
NCT03228823	UNKNOWN	Ventricular Premature Beats, Contractions, or Systoles; Cardiomyopathies	Hunter Holmes Mcguire Veteran Affairs Medical Center	2018-08-01	PHASE4
NCT04223739	UNKNOWN	Atrial Fibrillation; Cardiac Surgery	University Hospital, Caen	2019-12-13	PHASE4
NCT04351763	COMPLETED	COVID-19	Nicolaus Copernicus University	2020-05-20	PHASE2; PHASE3
NCT05058053	COMPLETED	Phlebitis	Saglik Bilimleri Universitesi	2020-03-01
NCT02924285	COMPLETED	Heart Diseases; Cardiomyopathies; Ventricular Premature Complexes	University of Leipzig	2017-11-01	PHASE3
NCT03842020	COMPLETED	Heart Rhythm Disorder	Assistance Publique - Hôpitaux de Paris	2019-02-13
NCT03720210	TERMINATED	Amiodarone-Induced Thyrotoxicosis	Mayo Clinic	2018-11-19
NCT03715556	UNKNOWN	Sepsis; Septic Shock; Atrial Fibrillation; Ventricular Fibrillation; Atrial Fibrillation Rapid	University of Sao Paulo General Hospital	2018-12-01	PHASE3
NCT04092621	UNKNOWN	New Onset Atrial Fibrillation; Sepsis; Respiratory Failure	Our Lady of the Lake Hospital	2019-09-16	PHASE4
NCT03193749	UNKNOWN	Chagas Cardiomyopathy	Fundación Cardioinfantil Instituto de Cardiología	2017-06-12	PHASE3
NCT03905759	UNKNOWN	Postoperative Atrial Fibrillation	doaa rashwan	2019-04-03	PHASE2; PHASE3
NCT03855826	UNKNOWN	Ventricular Tachycardia; Ventricular Fibrillation	Sichuan Baili Pharmaceutical Co., Ltd.	2019-01-15	PHASE4
NCT03299517	UNKNOWN	Arrhythmias Ventricular	University of Sao Paulo General Hospital	2017-08-02	PHASE4
NCT03221764	COMPLETED	Atrial Fibrillation; Lung Transplant; Complications	University of Louisville	2017-10-19	PHASE2
NCT02248753	COMPLETED	Atrial Fibrillation	Maastricht University Medical Center	2014-10
NCT02668432	TERMINATED	New Onset Atrial Fibrillation; Severe Sepsis; Septic Shock	The University of Texas Health Science Center at San Antonio	2016-05	PHASE4
NCT02294955	UNKNOWN	Atrial Fibrillation; Quality of Life	Uppsala University Hospital	2008-05
NCT02341105	TERMINATED	Atrial Fibrillation	Population Health Research Institute	2016-01	PHASE4
NCT02715687	UNKNOWN	Atrial Fibrillation	Rambam Health Care Campus	2016-03	PHASE3
NCT02145546	UNKNOWN	Atrial Fibrillation	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	2014-05	PHASE4
NCT03153072	WITHDRAWN	Supraventricular Tachycardia	Centre Hospitalier Universitaire, Amiens	2016-09-06	PHASE2
NCT03857711	UNKNOWN	Arrhythmias, Cardiac; Cardiovascular Diseases; Postoperative Atrial Fibrillation; Myocardial Ischemia	National Research Center of Surgery, Russia	2016-09-01
NCT01850277	UNKNOWN	Atrial Fibrillation; Heart Failure	National Institute of Cardiology, Warsaw, Poland	2013-10	PHASE4
NCT01511263	TERMINATED	Primary Amyloidosis of Light Chain Type	Fondazione IRCCS Policlinico San Matteo di Pavia	2012-01	PHASE2
NCT02301390	TERMINATED	Ventricular Tachycardia	Icahn School of Medicine at Mount Sinai	2009-10
NCT01627106	WITHDRAWN	Atrial Fibrillation	Advanz Pharma	2012-09	PHASE4
NCT01401647	COMPLETED	Cardiac Arrest	University of Washington	2012-05	PHASE3
NCT01276093	TERMINATED	Atrial Fibrillation	Abbott Medical Devices	2011-07
NCT02132767	COMPLETED	Postoperative Atrial Fibrillation	Icahn School of Medicine at Mount Sinai	2014-05	PHASE3
NCT01649544	TERMINATED	Mitral Valvulopathy; Atrial Fibrillation	Centre Hospitalier Universitaire de Saint Etienne	2012-03
NCT00721032	WITHDRAWN	Ventricular Tachycardia	Johns Hopkins University	2012-06
NCT02307591	WITHDRAWN	Ebola Virus Disease	Emergency NGO Onlus	2014-12	PHASE2; PHASE3
NCT01798277	WITHDRAWN	Ventricular Tachycardia; Coronary Artery Disease	Newmarket Electrophysiology Research Group Inc	2013-04	PHASE3
NCT01817439	UNKNOWN	Atrial Fibrillation	Western Galilee Hospital-Nahariya	2013-05	PHASE3
NCT01416935	TERMINATED	Atrial Fibrillation	Inova Health Care Services	2011-01-01
NCT01955759	UNKNOWN	Patients With Coronary Artery Disease Scheduled for by Pass Surgery	Heart Center BH Tuzla	2013-12	EARLY_PHASE1
NCT01341353	UNKNOWN	Atrial Fibrillation	Wuhan University	2011-04	PHASE4
NCT00729911	COMPLETED	Heart Failure	Texas Cardiac Arrhythmia Research Foundation	2008-10	PHASE4
NCT01181414	COMPLETED	Chronic Heart Failure; Cardiomyopathy, Dilated; Atrial Fibrillation	Hospital Clinic of Barcelona	2010-10	PHASE4
NCT01173809	COMPLETED	Atrial Fibrillation	Texas Cardiac Arrhythmia Research Foundation	2010-10	PHASE3
NCT01576042	TERMINATED	Ventricular Tachycardia	Duke University	2012-05
NCT00826826	COMPLETED	Atrial Fibrillation	Rigshospitalet, Denmark	2009-01
NCT01558830	UNKNOWN	Chronic Stable Angina; Coronary Artery Disease; Atrial Fibrillation; Ventricular Tachycardia	Cardiovascular Consultants of Nevada	2012-01	PHASE4
NCT01558128	TERMINATED	Cardiac Disease	Weill Medical College of Cornell University	2012-03
NCT01480336	COMPLETED	Arrhythmia	Hartford Hospital	2011-02
NCT01266681	UNKNOWN	Atrial Fibrillation	Eastbourne General Hospital	2011-03
NCT01199081	COMPLETED	Atrial Fibrillation	Sanofi	2010-10	PHASE4
NCT01097330	TERMINATED	Defibrillators, Implantable; Tachycardia, Ventricular	Population Health Research Institute	2010-08	PHASE3
NCT01709682	COMPLETED	Paroxysmal Atrial Fibrillation; Failed First Radiofrequency Ablation Procedure	Meshalkin Research Institute of Pathology of Circulation	2007-11	PHASE2
NCT00953212	COMPLETED	Atrial Fibrillation; Atrial Flutter	MaineHealth	2009-08	PHASE3
NCT01140581	COMPLETED	Atrial Fibrillation	Sanofi	2010-09	PHASE4
NCT00383799	TERMINATED	Ventricular Tachycardia; Wide QRS Tachycardia	Hospital General Universitario Gregorio Marañon	2005-09	PHASE4
NCT00993382	COMPLETED	Arrhythmia Prophylaxis; Ventricular Arrhythmia	Sanofi	2009-09	PHASE2
NCT01229254	COMPLETED	Atrial Fibrillation; Atrial Flutter	Portola Pharmaceuticals	2010-09	PHASE2
NCT00392106	SUSPENDED	Atrial Fibrillation	ProRhythm, Inc.	2006-04	PHASE3
NCT00587483	COMPLETED	Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery	Mayo Clinic	2007-11
NCT03432663	COMPLETED	Atrial Fibrillation	Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud	2008-08-01	PHASE4
NCT00300495	TERMINATED	Atrial Fibrillation; Lung Cancer	Beth Israel Deaconess Medical Center	2006-02	PHASE3
NCT00668759	COMPLETED	Atrial Fibrillation	Advanz Pharma	2008-04	PHASE3
NCT00724581	UNKNOWN	Atrial Fibrillation	Aarhus University Hospital	2008-08	PHASE4
NCT00784316	COMPLETED	Atrial Fibrillation; Cardiac Surgery	Kuopio University Hospital	2007-08	PHASE4
NCT01461733	COMPLETED	Atrial Fibrillation	Ottawa Hospital Research Institute	2007-07	PHASE4
NCT00845780	COMPLETED	Persistent Atrial Fibrillation	University Medical Center Groningen	2000-08	PHASE4
NCT00739193	WITHDRAWN	Blood Pressure	Prism Pharmaceuticals	2008-08	PHASE2
NCT00420017	COMPLETED	Atrial Fibrillation; Esophagectomy	Indiana University	2005-09	PHASE4
NCT00489736	COMPLETED	Atrial Fibrillation	Sanofi	2007-06	PHASE3
NCT00121524	COMPLETED	Cardiac Arrest	Petter Andreas Steen	2003-01	PHASE2
NCT01198275	COMPLETED	Atrial Fibrillation	Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia	2006-01	PHASE3
NCT00127712	COMPLETED	Atrial Fibrillation	Indiana University	2004-09	PHASE4
NCT00654290	COMPLETED	Atrial Fibrillation	Shiraz University of Medical Sciences	2007-03
NCT00313443	COMPLETED	Arrhythmia; Atrial Fibrillation; Atrial Flutter	Hopital Lariboisière	2006-04	PHASE4
NCT00420953	COMPLETED	Healthy	Prism Pharmaceuticals	2006-12-18	PHASE1
NCT00540787	COMPLETED	Paroxysmal Atrial Fibrillation	Biosense Webster, Inc.	2003-08-01	PHASE4
NCT02171026	COMPLETED	Healthy	Boehringer Ingelheim	2006-04	PHASE1
NCT00233441	COMPLETED	Atrial Fibrillation; Atrial Flutter	Sanofi	2004-12	PHASE2; PHASE3
NCT00007605	COMPLETED	Atrial Fibrillation; Cerebrovascular Accident; Death, Sudden	US Department of Veterans Affairs	1998-04	PHASE3
NCT00000464	COMPLETED	Arrhythmia; Cardiovascular Diseases; Heart Arrest; Heart Diseases; Myocardial Infarction; Ventricular Fibrillation	University of Washington	1987-04	PHASE3
NCT00392431	COMPLETED	Persistant Atrial Fibrillation	University Medical Center Groningen	2003-01
NCT00257959	COMPLETED	Ventricular Tachycardia	Connolly, Stuart, M.D.	2001-01	PHASE4
NCT00000556	COMPLETED	Arrhythmia; Atrial Fibrillation; Cardiovascular Diseases; Heart Diseases	National Heart, Lung, and Blood Institute (NHLBI)	1995-03	PHASE3
NCT00000609	COMPLETED	Arrhythmia; Cardiovascular Diseases; Death, Sudden, Cardiac; Heart Diseases; Heart Failure, Congestive; Heart Failure	National Heart, Lung, and Blood Institute (NHLBI)	1997-05	PHASE3
NCT00272636	COMPLETED	Atrial Fibrillation	University of Michigan	2002-11
NCT00287209	COMPLETED	Atrial Fibrillation; Coronary Artery Bypass Grafting	University of Aarhus	2004-01	PHASE4
NCT00251706	COMPLETED	Atrial Fibrillation	University of Calgary	1999-02	PHASE3
NCT00000531	COMPLETED	Arrhythmia; Cardiovascular Diseases; Death, Sudden, Cardiac; Heart Diseases; Tachycardia, Ventricular; Ventricular Fibrillation	National Heart, Lung, and Blood Institute (NHLBI)	1992-09	PHASE3

(data from https://clinicaltrials.gov, updated on 2026-02-17)

Check the Amiodarone HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Amiodarone HCl functions as a potassium channel and sodium/potassium-ATPase inhibitor, which alters transmembrane ionic flux, prolongs the cardiac action potential duration, and stimulates cellular autophagy. This electrophysiological stabilization suppresses ectopic pacemaker activity and stabilizes membrane potential, providing direct clinical utility in converting and managing cardiac dysrhythmias such as atrial fibrillation and supraventricular tachycardia.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).