CAS No. 1257517-67-1
| IUPAC Name | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;hydrate | |
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| CAS Number | 1257517-67-1 | |
| Molecular Formula |
C22H43N5O13.xH2O |
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| Molecular Weight (MW) | 585.6+x18 | |
| SMILES | C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N.O | |
| InChIKey | DTSOZYYWEZJFSS-XTHCGPPUSA-N |
Amikacin hydrate is a broad-spectrum aminoglycoside antibiotic that targets the bacterial 30S ribosomal subunit. By binding to 16S rRNA within the ribosomal A-site, amikacin interferes with translation accuracy, causes mRNA mistranslation, and halts protein synthesis. This disruption impairs essential cellular functions and bacterial membrane integrity, leading to bactericidal activity against susceptible Gram-negative and Gram-positive bacterial pathogens.
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