AMG 193 is a potent, selective, and orally bioavailable MTA-cooperative PRMT5 inhibitor. It affects PRMT5-mediated methylation signaling by specifically binding to the PRMT5-MTA complex, effectively inhibiting symmetric dimethylarginine (SDMA) modification and suppressing tumor cell proliferation in MTAP-deleted cancers.
AMG 193 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for AMG 193 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.