CAS No. 2790567-82-5

Batch: Purity:97.87
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AMG 193 Chemical Structure
Chemical Structure
Check the AMG 193 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4-amino-1,3-dihydrofuro[3,4-c][1,7]naphthyridin-8-yl)-[(3S)-3-[4-(trifluoromethyl)phenyl]morpholin-4-yl]methanone
CAS Number 2790567-82-5
Molecular Formula

C22H19F3N4O3
Molecular Weight (MW) 444.41
InChIKey BFEBTMFPRJPBTK-LJQANCHMSA-N

Ordering Information

Biological Activity

AMG 193 is an orally active, MTA-cooperative inhibitor of protein arginine methyltransferase 5 (PRMT5) that selectively targets MTAP-deficient tumor cells over normal wild-type cells. By preferentially binding PRMT5 in the presence of methylthioadenosine, it suppresses methyltransferase activity to induce DNA damage, cell cycle arrest, and aberrant alternative mRNA splicing. Consequently, AMG 193 inhibits cell proliferation with approximately 40-fold selectivity and drives robust antitumor efficacy in preclinical xenograft models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 30 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.