CAS No. 183232-66-8
| IUPAC Name | 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide | |
|---|---|---|
| CAS Number | 183232-66-8 | |
| Molecular Formula |
C22H21Cl2IN4O |
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| Molecular Weight (MW) | 555.24 | |
| SMILES | CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I | |
| InChIKey | BUZAJRPLUGXRAB-UHFFFAOYSA-N |
AM251 is a selective cannabinoid CB1 receptor antagonist and inverse agonist. It blocks the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on neurotransmitter release by acting at presynaptic CB1 receptors in the brain. Inhibition of presynaptic CB1 receptors blocks G-protein-mediated signaling pathways, reversing agonist-induced suppression of neurotransmitter release and modulating synaptic plasticity and neurochemical transmission. [1]
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Concentration
Volume
Mass
|
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| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(72.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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