CAS No. 467214-21-7

Batch: Purity:99.92
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Alvespimycin (17-DMAG) Hydrochloride Chemical Structure
Chemical Structure
Check the Alvespimycin (17-DMAG) Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate;hydrochloride
CAS Number 467214-21-7
Molecular Formula

C32H48N4O8•HCl
Molecular Weight (MW) 653.21
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
InChIKey DFSYBWLNYPEFJK-IHLRWNDRSA-N

Biological Activity

Alvespimycin (17-DMAG) Hydrochloride is a potent and selective HSP90 inhibitor with an IC50 of 62 nM in a cell-free assay and a mean GI50 of 53 nM. It binds to the ATP-binding site in the N-terminal domain of HSP90, disrupting chaperone activity and inducing the degradation of client proteins. This inhibition suppresses oncogenic signaling pathways, leading to antiproliferative and antitumor phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (153.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.