CAS No. 6147-11-1
Batch:
Purity:98.56
Chemical Structure
Check the
Alpha-Mangostin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | |
|---|---|---|
| CAS Number | 6147-11-1 | |
| Molecular Formula |
C24H26O6 |
|
| Molecular Weight (MW) | 410.46 | |
| SMILES | CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)OC)CC=C(C)C)O)C | |
| InChIKey | GNRIZKKCNOBBMO-UHFFFAOYSA-N |
Alpha-mangostin is a dietary xanthone that acts as an inhibitor of mutant IDH1-R132H (Ki 2.85 μM) and serves as a STING agonist. By selectively targeting mutant IDH1, it disrupts altered cellular metabolism and reduces downstream 2-hydroxyglutarate production. Furthermore, STING activation modulates innate immune signaling pathways, promoting pro-inflammatory cytokine expression and triggering apoptotic cell death in cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 82 mg/mL |
| Water | Insoluble |
| DMSO |
82 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.