CAS No. 27013-91-8

Batch: Purity:99.74
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α-Hederin Chemical Structure
Chemical Structure
Check the α-Hederin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 27013-91-8
Molecular Formula

C41H66O12
Molecular Weight (MW) 750.96
SMILES CC1C(C(C(C(O1)OC2C(C(COC2OC3CCC4(C(C3(C)CO)CCC5(C4CC=C6C5(CCC7(C6CC(CC7)(C)C)C(=O)O)C)C)C)O)O)O)O)O

Biological Activity

α-Hederin is a water-soluble pentacyclic triterpenoid saponin that exhibits marked hemolytic and apoptotic properties. The compound disrupts cellular membrane integrity and alters lipid bilayer fluidity, triggering intracellular glutathione depletion and reactive oxygen species accumulation. These upstream events induce mitochondrial membrane depolarization and cytochrome c release, subsequently activating downstream apoptotic pathways, including caspase-3 activation, to drive programmed cell death in various cancer model systems. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (133.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Rooney S, et al. Anticancer Res. 2005;25(6B):4255-9.

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Note: Technical data last updated: Sep 1, 2026.