CAS No. 39674-97-0
Batch:
Purity:99.77
Chemical Structure
Check the
BVT-948
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3,3-dimethyl-1H-benzo[g]indole-2,4,5-trione | |
|---|---|---|
| CAS Number | 39674-97-0 | |
| Molecular Formula |
C14H11NO3 |
|
| Molecular Weight (MW) | 241.24 | |
| SMILES | CC1(C)C(=O)N=C2C3=CC=CC=C3C(=O)C(=C12)O | |
| InChIKey | LLPBUXODFQZPFH-UHFFFAOYSA-N |
BVT-948 is a cell-permeable, irreversible, and noncompetitive protein tyrosine phosphatase (PTP) inhibitor that targets PTP1B, TCPTP, SHP-2, LAR, and YopH. By inhibiting PTP activity, BVT-948 prevents substrate dephosphorylation, maintaining tyrosine kinase-mediated phosphorylation states within crucial signal transduction networks. Consequently, this target blockade modulates downstream metabolic pathways and cellular signaling events regulated by protein tyrosine phosphatases. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
48 mg/mL
(198.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.